KEGG   ENZYME: 2.6.1.88Help
Entry
EC 2.6.1.88                 Enzyme                                 

Name
methionine transaminase;
methionine-oxo-acid transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-methionine:2-oxo-acid aminotransferase
Reaction(IUBMB)
L-methionine + a 2-oxo carboxylate = 2-oxo-4-methylthiobutanoate + an L-amino acid [RN:R08618]
Reaction(KEGG)
Substrate
L-methionine [CPD:C00073];
2-oxo carboxylate [CPD:C00161]
Product
2-oxo-4-methylthiobutanoate [CPD:C01180];
L-amino acid [CPD:C00151]
Comment
The enzyme is most active with L-methionine. It participates in the L-methionine salvage pathway from S-methyl-5'-thioadenosine, a by-product of polyamine biosynthesis. The enzyme from the bacterium Klebsiella pneumoniae can use several different amino acids as amino donor, with aromatic amino acids being the most effective [1]. The enzyme from the plant Arabidopsis thaliana is also a part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates [3].
History
EC 2.6.1.88 created 2011
Reference
1  [PMID:10074065]
  Authors
Heilbronn J, Wilson J, Berger BJ.
  Title
Tyrosine aminotransferase catalyzes the final step of methionine recycling in Klebsiella pneumoniae.
  Journal
J. Bacteriol. 181 (1999) 1739-47.
  Organism
Klebsiella pneumoniae
  Sequence
[up:O85746]
Reference
2  [PMID:15280032]
  Authors
Dolzan M, Johansson K, Roig-Zamboni V, Campanacci V, Tegoni M, Schneider G, Cambillau C
  Title
Crystal structure and reactivity of YbdL from Escherichia coli identify a methionine aminotransferase function.
  Journal
FEBS. Lett. 571 (2004) 141-6.
  Organism
Escherichia coli
  Sequence
[eco:b0600]
Reference
3  [PMID:17056707]
  Authors
Schuster J, Knill T, Reichelt M, Gershenzon J, Binder S
  Title
Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis.
  Journal
Plant. Cell. 18 (2006) 2664-79.
  Organism
Arabidopsis thaliana
  Sequence
[up:Q9LE06]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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