KEGG   ENZYME: 2.6.1.96Help
Entry
EC 2.6.1.96                 Enzyme                                 

Name
4-aminobutyrate---pyruvate transaminase;
aminobutyrate aminotransferase (ambiguous);
gamma-aminobutyrate aminotransaminase (ambiguous);
gamma-aminobutyrate transaminase (ambiguous);
gamma-aminobutyric acid aminotransferase (ambiguous);
gamma-aminobutyric acid pyruvate transaminase;
gamma-aminobutyric acid transaminase (ambiguous);
gamma-aminobutyric transaminase (ambiguous);
4-aminobutyrate aminotransferase (ambiguous);
4-aminobutyric acid aminotransferase (ambiguous);
aminobutyrate transaminase (ambiguous);
GABA aminotransferase (ambiguous);
GABA transaminase (ambiguous);
GABA transferase;
POP2 (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
4-aminobutanoate:pyruvate aminotransferase
Reaction(IUBMB)
(1) 4-aminobutanoate + pyruvate = succinate semialdehyde + L-alanine [RN:R10178];
(2) 4-aminobutanoate + glyoxylate = succinate semialdehyde + glycine [RN:R10179]
Reaction(KEGG)
Substrate
4-aminobutanoate [CPD:C00334];
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Product
succinate semialdehyde [CPD:C00232];
L-alanine [CPD:C00041];
glycine [CPD:C00037]
Comment
Requires pyridoxal 5'-phosphate. The enzyme is found in plants that do not have the 2-oxoglutarate dependent enzyme (cf. EC 2.6.1.19). The reaction with pyruvate is reversible while the reaction with glyoxylate only takes place in the forward direction.
History
EC 2.6.1.96 created 2012
Pathway
Alanine, aspartate and glutamate metabolism
Butanoate metabolism
Metabolic pathways
Orthology
K16871  
4-aminobutyrate---pyruvate transaminase
Genes
AQU: 
ATH: 
AT3G22200(POP2)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
POPTR_0006s02170g(POPTRDRAFT_652454)
VVI: 
SLY: 
543873(GABA-TP1) 544258(GABA-TP3)
SOT: 
OSA: 
DOSA: 
Os04t0614600-01(Os04g0614600) Os08t0205900-01(Os08g0205900)
BDI: 
SBI: 
SORBI_06g028440(SORBIDRAFT_06g028440) SORBI_07g005930(SORBIDRAFT_07g005930)
ZMA: 
SITA: 
SMO: 
PPP: 
GTT: 
PPU: 
PPUH: 
PRE: 
PSK: 
CPS: 
BAC: 
BYI: 
BPE: 
BPC: 
BPER: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
BPT: 
BAV: 
PUT: 
AKA: 
POL: 
VEI: 
VAP: 
VPD: 
MCI: 
PLA: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
BN406_06293(GABA-TP3)
SMEG: 
SMEL: 
SMD: 
ATU: 
ARA: 
Arad_9339(bioA)
AGR: 
RET: 
REC: 
REL: 
RTR: 
RIR: 
BME: 
BMI: 
BMZ: 
BMG: 
BMW: 
BMF: 
BMB: 
BMC: 
BAA: 
BMS: 
BSI: 
BMT: 
BSV: 
BOV: 
BCS: 
BSK: 
BMR: 
BPP: 
BCET: 
BCEE: 
OAN: 
BJA: 
BJU: 
BBT: 
BRS: 
RPB: 
SNO: 
MEX: 
MEA: 
MDI: 
MCH: 
MRD: 
MET: 
MPO: 
MNO: 
RSP: 
RSP_3261(bioA)
RSH: 
RSQ: 
RSK: 
RDE: 
RLI: 
PAMI: 
PGA: 
PGL: 
PGD: 
LMD: 
RRU: 
RRF: 
RCE: 
RPM: 
MAG: 
MGY: 
AZL: 
ALI: 
ABS: 
TMO: 
PGV: 
SSX: 
MRE: 
 » show all
Taxonomy
Reference
1
  Authors
Van Cauwenberghe, O.R. and Shelp, B.J.
  Title
Biochemical characterization of partially purified gaba:pyruvate transaminase from Nicotiana tabacum.
  Journal
Phytochemistry 52 (1999) 575-581.
Reference
2  [PMID:12859897]
  Authors
Palanivelu R, Brass L, Edlund AF, Preuss D
  Title
Pollen tube growth and guidance is regulated by POP2, an Arabidopsis gene that controls GABA levels.
  Journal
Cell. 114 (2003) 47-59.
  Organism
Arabidopsis thaliana [GN:ath]
  Sequence
[ath:AT3G22200]
Reference
3  [PMID:19264755]
  Authors
Clark SM, Di Leo R, Dhanoa PK, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate.
  Journal
J. Exp. Bot. 60 (2009) 1743-57.
  Organism
Arabidopsis thaliana [GN:ath]
  Sequence
[ath:AT3G22200]
Reference
4  [PMID:19470656]
  Authors
Clark SM, Di Leo R, Van Cauwenberghe OR, Mullen RT, Shelp BJ
  Title
Subcellular localization and expression of multiple tomato gamma-aminobutyrate transaminases that utilize both pyruvate and glyoxylate.
  Journal
J. Exp. Bot. 60 (2009) 3255-67.
  Organism
Solanum lycopersicum [GN:sly]
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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