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Entry
EC 2.6.1.97                 Enzyme                                 

Name
archaeosine synthase;
ArcS;
TgtA2;
MJ1022 (gene name);
glutamine:preQ0-tRNA amidinotransferase (incorrect)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
L-glutamine:7-cyano-7-carbaguanine aminotransferase
Reaction(IUBMB)
L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA
Substrate
L-glutamine [CPD:C00064];
7-cyano-7-carbaguanine15 in tRNA;
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
archaeine15 in tRNA
Comment
In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase [2]. The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors.
History
EC 2.6.1.97 created 2012
Orthology
K07557  
archaeosine synthase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_4632(tgt)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMAZ: 
MMJ: 
MMAC: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MHAZ: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MEMA: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
LRC280(tgt-1)
MTH: 
MMG: 
METC: 
MWO: 
MST: 
MSI: 
MRU: 
MEB: 
MMIL: 
sm9_0339(tgtA)
MEYE: 
MOL: 
MEL: 
MEW: 
METH: 
MFC: 
MFI: 
MCUB: 
MCBB_0612(arcS1)
MFV: 
MKA: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
HAL: 
VNG_1957G(tgtA2)
HSL: 
OE_3748R(arcS)
HDL: 
HHB: 
Hhub_3274(arcS)
HJE: 
HMA: 
HHI: 
HAH_0506(tgt2)
HHN: 
HAB: 
NPH: 
NP_2506A(arcS)
NMO: 
Nmlp_3874(arcS)
HUT: 
HTI: 
HMU: 
HALI: 
HSU: 
HLASF_1960(tgtA2)
HSF: 
HLASA_1946(tgtA2)
HVO: 
HVO_2008(tgtA2)
HME: 
HGI: 
HBO: 
HLA: 
HTU: 
HDA: 
NMG: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
HLR: 
HLC: 
HALH: 
HTSR_1955(tgtA2)
HHSR: 
HSR6_2030(tgtA2)
TAC: 
TVO: 
TVG1126727(TVG1126727)
PTO: 
FAC: 
CDIV: 
TAR: 
MAX: 
MER: 
MEAR: 
MARC: 
PHO: 
PH0135(PH0135)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
TCH: 
PPAC: 
ABI: 
ACF: 
IHO: 
TPE: 
LOKI: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:20129918]
  Authors
Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crecy-Lagard V
  Title
Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA.
  Journal
J. Biol. Chem. 285 (2010) 12706-13.
  Sequence
[mja:MJ_1022]
Reference
2  [PMID:22032275]
  Authors
Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crecy-Lagard V
  Title
Diversity of archaeosine synthesis in crenarchaeota.
  Journal
ACS. Chem. Biol. 7 (2012) 300-5.
  Sequence
[mja:MJ_1022]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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