KEGG   ENZYME: 2.6.1.98Help
Entry
EC 2.6.1.98                 Enzyme                                 

Name
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase;
WbpE;
WlbC
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate:2-oxoglutarate aminotransferase
Reaction(IUBMB)
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate [RN:R10141]
Reaction(KEGG)
Substrate
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:C20359];
2-oxoglutarate [CPD:C00026]
Product
UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate [CPD:C20395];
L-glutamate [CPD:C00025]
Comment
A pyridoxal 5'-phosphate protein. This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the previous enzyme in the pathway, EC 1.1.1.335 (UDP-N-acetyl-2-amino-2-deoxyglucuronate oxidase).
History
EC 2.6.1.98 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K13017  
UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase
Genes
PLU: 
plu4799(wblD)
PAY: 
PAU_04314(wblD)
PTT: 
XBO: 
XNE: 
XNM: 
MSU: 
MS1498(wecE)
ASU: 
DJI: 
DJA: 
PAE: 
PA3155(wbpE)
PAEV: 
N297_3266(wbpE)
PAEI: 
N296_3266(wbpE)
PAEM: 
PAEC: 
M802_3264(wbpE)
PAEO: 
M801_3131(wbpE)
PMY: 
PPUH: 
PBA: 
PDR: 
PSES: 
PSOS: 
PCR: 
PRW: 
PALI: 
ACB: 
ABK: 
ABW: 
ACC: 
ACD: 
MSR: 
MARI: 
CBU: 
CBS: 
CBD: 
CBG: 
CBC: 
CEA: 
CEY: 
LPN: 
LPH: 
LPO: 
LPU: 
LPM: 
LP6_1405(dnrJ)
LPF: 
LPP: 
LPC: 
LPA: 
LPE: 
LLO: 
LFA: 
LFA_1370(wbpE)
LHA: 
LHA_1875(degT)
LOK: 
TMC: 
LMI_1805(degT)
TIG: 
BLEP: 
ALV: 
TVI: 
TMB: 
MPUR: 
TNI: 
TVNIR_0691(degT_[H])
TTI: 
HCO: 
ADI: 
MMW: 
TOR: 
SDF: 
SEDS: 
NEL: 
CVI: 
LHK: 
PSE: 
RPJ: 
REH: 
H16_B0031(wbpE)
PPNO: 
BPE: 
BP0091(bplC)
BPC: 
BPTD_0087(bplC)
BPER: 
BPET: 
BPEU: 
Q425_2040(bplC)
BPA: 
BPP0153(bplC)
BPAR: 
BBR: 
BB0153(bplC)
BBM: 
BBH: 
BBX: 
BPT: 
Bpet4818(wlbC)
BAV: 
BAV0096(wlbC)
BHO: 
D560_1330(wbpE)
BHM: 
D558_1319(wbpE)
BHZ: 
BTRM: 
AXY: 
AXN: 
AXS: 
TEQ: 
TEA: 
TEG: 
PNA: 
AAV: 
AJS: 
ACK: 
VAP: 
VPE: 
VPD: 
CTES: 
HSE: 
MASW: 
LCH: 
RGE: 
RBN: 
RDP: 
PKT: 
MIU: 
APP: 
HHE: 
HH_0627(wlaK)
HMS: 
HBI: 
HCP: 
HCN_0250(wlaK)
HCB: 
HTY: 
WSU: 
WS2186(WLBC)
TDN: 
CJB: 
CJN: 
CJI: 
CJM: 
CJM1_0483(degT)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJV: 
CJY: 
CJQ: 
UC78_0492(wbpE)
CJL: 
CJW: 
CJZ: 
CJX: 
CCV: 
CCO: 
CLR: 
CLM: 
CLQ: 
CLN: 
CLL: 
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
CIS: 
CVO: 
CPEL: 
CAMR: 
CSM: 
CSF: 
ABU: 
ANT: 
NIS: 
SUN: 
GLO: 
GEB: 
GSB: 
BBAT: 
BBAC: 
BEX: 
DOL: 
HNI: 
LAP: 
PUV: 
PUV_00150(degT)
WCH: 
wcw_1823(wbpE)
TPX: 
BRM: 
BPO: 
BPJ: 
BPIP: 
BPW: 
BIP: 
ABA: 
ACA: 
FSC: 
ZGA: 
TTK: 
TST_1661(wbpE)
DIN: 
 » show all
Taxonomy
Reference
1  [PMID:19282284]
  Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
  Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the  biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas  aeruginosa.
  Journal
J. Biol. Chem. 284 (2009) 11854-62.
  Sequence
[pae:PA3155]
Reference
2  [PMID:19348502]
  Authors
Larkin A, Imperiali B
  Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry. 48 (2009) 5446-55.
  Sequence
[pae:PA3155]
Reference
3  [PMID:20604544]
  Authors
Larkin A, Olivier NB, Imperiali B
  Title
Structural analysis of WbpE from Pseudomonas aeruginosa PAO1: a nucleotide sugar  aminotransferase involved in O-antigen assembly.
  Journal
Biochemistry. 49 (2010) 7227-37.
  Sequence
[pae:PA3155]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system