KEGG   ENZYME: 2.6.99.1Help
Entry
EC 2.6.99.1                 Enzyme                                 

Name
dATP(dGTP)---DNA purinetransferase
Class
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
BRITE hierarchy
Sysname
dATP(dGTP):depurinated-DNA purine transferase
Reaction(IUBMB)
(1) dATP + depurinated DNA = deoxyribose triphosphate + DNA [RN:R03904];
(2) dGTP + depurinated DNA = deoxyribose triphosphate + DNA [RN:R07278]
Reaction(KEGG)
Substrate
dATP [CPD:C00131];
depurinated DNA [CPD:C02270];
dGTP [CPD:C00286]
Product
deoxyribose triphosphate [CPD:C12347];
DNA [CPD:C00039]
Comment
The purine residue is transferred on to the apurinic site forming a normal glycosylic bond. dATP reacts at sites of the double-stranded depurinated DNA that lack adenine, and dGTP at sites that lack guanine.
History
EC 2.6.99.1 created 1984
Reference
1  [PMID:218192]
  Authors
Deutsch WA, Linn S.
  Title
DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 141-4.
Reference
2  [PMID:375225]
  Authors
Livneh Z, Elad D, Sperling J.
  Title
Enzymatic insertion of purine bases into depurinated DNA in vitro.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 76 (1979) 1089-93.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system