KEGG   ENZYME: 2.7.1.103Help
Entry
EC 2.7.1.103                Enzyme                                 

Name
viomycin kinase;
viomycin phosphotransferase;
capreomycin phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:viomycin O-phosphotransferase
Reaction(IUBMB)
ATP + viomycin = ADP + O-phosphoviomycin [RN:R03607]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
viomycin [CPD:C01540]
Product
ADP [CPD:C00008];
O-phosphoviomycin [CPD:C02574]
Comment
Acts also on capreomycins. A serine residue in the peptide antibiotics acts as phosphate-acceptor.
History
EC 2.7.1.103 created 1983
Reference
1  [PMID:6163840]
  Authors
Skinner RH, Cundliffe E.
  Title
Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them.
  Journal
J. Gen. Microbiol. 120 (1980) 95-104.
  Organism
Streptomyces capreolus, Streptomyces vinaceus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
77000-11-4

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