KEGG   ENZYME: 2.7.1.119Help
Entry
EC 2.7.1.119                Enzyme                                 

Name
hygromycin-B 7''-O-kinase;
hygromycin B phosphotransferase;
hygromycin-B kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:hygromycin-B 7''-O-phosphotransferase
Reaction(IUBMB)
ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B [RN:R03770]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
hygromycin B [CPD:C01925]
Product
ADP [CPD:C00008];
7''-O-phosphohygromycin B
Comment
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.
History
EC 2.7.1.119 created 1989, modified 2009, modified 2011
Orthology
K17880  
hygromycin-B 7''-O-kinase
Genes
SDN: 
SSE: 
SPL: 
SVO: 
SCU: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
AOL: 
SCO: 
SCO3277(SCE39.27c)
SMA: 
SCB: 
SVE: 
SDV: 
KRA: 
AOI: 
AMI: 
SESP: 
AFS: 
 » show all
Taxonomy
Reference
1  [PMID:3026811]
  Authors
Zalacain M, Pardo JM, Jimenez A.
  Title
Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.
  Journal
Eur. J. Biochem. 162 (1987) 419-22.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
88361-67-5

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