KEGG   ENZYME: 2.7.1.136Help
Entry
EC 2.7.1.136                Enzyme                                 

Name
macrolide 2'-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:macrolide 2'-O-phosphotransferase
Reaction(IUBMB)
ATP + oleandomycin = ADP + oleandomycin 2'-O-phosphate [RN:R03780]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
oleandomycin [CPD:C01946]
Product
ADP [CPD:C00008];
oleandomycin 2'-O-phosphate [CPD:C03796]
Comment
Erythromycin, spiramycin and some other macrolide antibiotics can also act as acceptors.
History
EC 2.7.1.136 created 1992
Reference
1  [PMID:3042731]
  Authors
O'Hara K, Kanda T, Kono M.
  Title
Structure of a phosphorylated derivative of oleandomycin, obtained by reaction of oleandomycin with an extract of an erythromycin-resistant strain of Escherichia coli.
  Journal
J. Antibiot. (Tokyo). 41 (1988) 823-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
116036-69-2

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