KEGG   ENZYME: 2.7.1.140Help
Entry
EC 2.7.1.140                Enzyme                                 

Name
inositol-tetrakisphosphate 5-kinase;
1D-myo-inositol-tetrakisphosphate 5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:R03478]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4,6-tetrakisphosphate [CPD:C04477]
Product
ADP [CPD:C00008];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Comment
The enzyme from plants and yeast can also use Ins(1,2,3,4,6)P5 as a substrate [2].
History
EC 2.7.1.140 created 1992
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K00915  
1D-myo-Inositol-tetrakisphosphate 5-kinase / inositol-polyphosphate multikinase
Genes
ATH: 
AT5G07370(IPK2a) AT5G61760(IPK2BETA)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
100127407(IPK2)
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0012s11320g(POPTRDRAFT_423081) POPTR_0015s12100g(POPTRDRAFT_253088)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0523800-01(Os02g0523800)
OBR: 
BDI: 
SBI: 
SORBI_04g021290(SORBIDRAFT_04g021290)
ZMA: 
SITA: 
ATR: 
s00016p00249320(AMTR_s00016p00249320)
SMO: 
PPP: 
CRE: 
VCN: 
BPG: 
CSL: 
 » show all
Taxonomy
Reference
1  [PMID:2584198]
  Authors
Shears SB.
  Title
The pathway of myo-inositol 1,3,4-trisphosphate phosphorylation in liver. Identification of myo-inositol 1,3,4-trisphosphate 6-kinase, myo-inositol 1,3,4-trisphosphate 5-kinase, and myo-inositol 1,3,4,6-tetrakisphosphate 5-kinase.
  Journal
J. Biol. Chem. 264 (1989) 19879-86.
  Organism
Rattus norvegicus
Reference
2  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J. Biol. Chem. 277 (2002) 42711-8.
  Organism
Arabidopsis thaliana
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
123940-40-9

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