KEGG   ENZYME: 2.7.1.146Help
Entry
EC 2.7.1.146                Enzyme                                 

Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
History
EC 2.7.1.146 created 2001
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Biosynthesis of antibiotics
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase
Genes
RLT: 
TCO: 
CSH: 
LPIL: 
MIM: 
ARE: 
ARW: 
SKE: 
TPY: 
TPYO: 
ABAO: 
SSM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMP1296(pfkC)
MMQ: 
MMX: 
MMZ: 
MMD: 
MMAK: 
MMAO: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MA_3562(glkA) MA_3563(pfk)
MBA: 
MBY: 
MBW: 
MBAR: 
MBAK: 
MMA: 
MMJ: 
MVC: 
MEK: 
MLS: 
METM: 
MEF: 
MEQ: 
MSJ: 
MSZ: 
MSW: 
MTHE: 
MTHR: 
MHOR: 
MBU: 
MMET: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MCON_0234(pfkC)
MBN: 
NMG: 
NGE: 
HRU: 
PHO: 
PH0589(PH0589) PH1645(PH1645)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TON: 
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TGY: 
THV: 
TCH: 
PPAC: 
NAC: 
 » show all
Taxonomy
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 274 (1999) 21023-8.
  Sequence
[pfu:PF1784]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
237739-62-7

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