KEGG   ENZYME: 2.7.1.146Help
Entry
EC 2.7.1.146                Enzyme                                 
Name
ADP-specific phosphofructokinase;
ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-fructose-6-phosphate 1-phosphotransferase
Reaction(IUBMB)
ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate [RN:R05805]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-fructose 6-phosphate [CPD:C00085]
Product
AMP [CPD:C00020];
D-fructose 1,6-bisphosphate [CPD:C00354]
Comment
ADP can be replaced by GDP, ATP and GTP, to a limited extent. Divalent cations are necessary for activity, with Mg2+ followed by Co2+ being the most effective.
Pathway
Glycolysis / Gluconeogenesis
Pentose phosphate pathway
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase
Genes
RLT: 
TCO: 
CSH: 
SKE: 
SSM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
Metig_1734
MMP: 
MMP1296(pfkC)
MMQ: 
MmarC5_0297
MMX: 
MmarC6_1378
MMZ: 
MmarC7_0541
MMD: 
GYY_07315
MAE: 
Maeo_0005
MVN: 
Mevan_0606
MVO: 
Mvol_0050 Mvol_0110
MOK: 
Metok_1190
MAC: 
MA3562(glkA) MA3563(pfk)
MBA: 
Mbar_A2004 Mbar_A2005
MMA: 
MM_0472 MM_0473
MBU: 
Mbur_1338 Mbur_1339
MMH: 
Mmah_1645 Mmah_1646
MEV: 
Metev_0816 Metev_0817
MZH: 
Mzhil_0819 Mzhil_0820
MPY: 
Mpsy_1159 Mpsy_1160
MHZ: 
Metho_2034 Metho_2035
MTP: 
Mthe_1214
MCJ: 
MCON_0234(pfkC)
MBN: 
Mboo_1525
NMG: 
Nmag_3826
NGE: 
Natgr_2898
HRU: 
Halru_0715 Halru_2961
PHO: 
PH0589 PH1645
PAB: 
PAB0967 PAB2013
PFU: 
PF0312 PF1784
PFI: 
PFC_00640 PFC_09670
PYN: 
PNA2_0229 PNA2_1204
PYA: 
PYCH_02450 PYCH_10910
PYS: 
Py04_0618 Py04_1537
TKO: 
TK0376 TK1110
TON: 
TON_0246 TON_1012
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TSIB_0252 TSIB_1220
TBA: 
TERMP_00004 TERMP_01160
THE: 
GQS_04080 GQS_10400
THA: 
TAM4_1728 TAM4_738
THM: 
CL1_0470 CL1_1657
 » show all
Taxonomy
Reference
1  [PMID:10409652]
  Authors
Tuininga JE, Verhees CH, van der Oost J, Kengen SW, Stams AJ, de Vos WM.
  Title
Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 274 (1999) 21023-8.
  Organism
Pyrococcus furiosus [GN:pfu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
237739-62-7
DBGET integrated database retrieval system