KEGG   ENZYME: 2.7.1.147Help
Entry
EC 2.7.1.147                Enzyme                                 
Name
ADP-specific glucokinase;
ADP-dependent glucokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-glucose 6-phosphotransferase
Reaction(IUBMB)
ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-glucose [CPD:C00031]
Product
AMP [CPD:C00020];
D-glucose 6-phosphate [CPD:C00092]
Comment
Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
Pathway
Glycolysis / Gluconeogenesis
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00918  
ADP-dependent phosphofructokinase/glucokinase
K08074  
ADP-dependent glucokinase
Genes
HSA: 
83440(ADPGK)
PTR: 
748791(ADPGK)
PPS: 
100988588(ADPGK)
GGO: 
101140731(ADPGK)
PON: 
100173850(ADPGK)
MCC: 
699257(ADPGK)
MMU: 
72141(Adpgk)
RNO: 
315722(Adpgk)
CFA: 
478360(ADPGK)
AML: 
100473629(ADPGK)
FCA: 
101088581(ADPGK)
BTA: 
518158(ADPGK)
SSC: 
100623786
ECB: 
100052166(ADPGK)
MDO: 
100016323
SHR: 
100921460(ADPGK)
OAA: 
100077123
GGA: 
415317(ADPGK)
MGP: 
100544507
TGU: 
100230242(ADPGK)
ACS: 
100567625
XTR: 
100489920
DRE: 
557919(adpgk)
TRU: 
101076196 101076203
OLA: 
101160066 101160396
BFO: 
BRAFLDRAFT_115435
CIN: 
100175704
SPU: 
588810
DME: 
Dmel_CG6650
DPO: 
Dpse_GA19752
DAN: 
Dana_GF24587
DER: 
Dere_GG15667
DPE: 
Dper_GL25288
DSE: 
Dsec_GM25447
DSI: 
Dsim_GD14473
DWI: 
Dwil_GK17138
DYA: 
Dyak_GE21996
DGR: 
Dgri_GH15105
DMO: 
Dmoj_GI13756
DVI: 
Dvir_GJ13747
AGA: 
AgaP_AGAP006394
ISC: 
IscW_ISCW023752
CEL: 
CELE_C50D2.7(C50D2.7)
CBR: 
CBG06989
BMY: 
Bm1_43195
TSP: 
Tsp_05422
NVE: 
NEMVE_v1g230488
HMG: 
100213786
TAD: 
TRIADDRAFT_54192
AQU: 
100635428 100640936
DPP: 
DICPUDRAFT_50094
PIF: 
PITG_11459
RLT: 
Rleg2_4979
TCO: 
Theco_1176
CSH: 
Closa_0608
SKE: 
Sked_02970
SSM: 
Spirs_3399
MJA: 
MJ_1604
MFE: 
Mefer_1517
MVU: 
Metvu_0786
MFS: 
MFS40622_0160
MIF: 
Metin_0227
MIG: 
Metig_1734
MMP: 
MMP1296(pfkC)
MMQ: 
MmarC5_0297
MMX: 
MmarC6_1378
MMZ: 
MmarC7_0541
MMD: 
GYY_07315
MAE: 
Maeo_0005
MVN: 
Mevan_0606
MVO: 
Mvol_0050 Mvol_0110
MOK: 
Metok_1190
MAC: 
MA3562(glkA) MA3563(pfk)
MBA: 
Mbar_A2004 Mbar_A2005
MMA: 
MM_0472 MM_0473
MBU: 
Mbur_1338 Mbur_1339
MMH: 
Mmah_1645 Mmah_1646
MEV: 
Metev_0816 Metev_0817
MZH: 
Mzhil_0819 Mzhil_0820
MPY: 
Mpsy_1159 Mpsy_1160
MHZ: 
Metho_2034 Metho_2035
MTP: 
Mthe_1214
MCJ: 
MCON_0234(pfkC)
MBN: 
Mboo_1525
NMG: 
Nmag_3826
NGE: 
Natgr_2898
HRU: 
Halru_0715 Halru_2961
PHO: 
PH0589 PH1645
PAB: 
PAB0967 PAB2013
PFU: 
PF0312 PF1784
PFI: 
PFC_00640 PFC_09670
PYN: 
PNA2_0229 PNA2_1204
PYA: 
PYCH_02450 PYCH_10910
PYS: 
Py04_0618 Py04_1537
TKO: 
TK0376 TK1110
TON: 
TON_0246 TON_1012
TGA: 
TGAM_0818(glkA) TGAM_1465(pfkC)
TSI: 
TSIB_0252 TSIB_1220
TBA: 
TERMP_00004 TERMP_01160
THE: 
GQS_04080 GQS_10400
THA: 
TAM4_1728 TAM4_738
THM: 
CL1_0470 CL1_1657
 » show all
Taxonomy
Reference
1  [PMID:8530474]
  Authors
Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM.
  Title
Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J. Biol. Chem. 270 (1995) 30453-7.
  Organism
Pyrococcus furiosus [GN:pfu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
173585-07-4
DBGET integrated database retrieval system