KEGG   ENZYME: 2.7.1.157Help
Entry
EC 2.7.1.157                Enzyme                                 

Name
N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase
Reaction(IUBMB)
ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine
Product
ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]
Comment
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
History
EC 2.7.1.157 created 2005
Reference
1  [PMID:8702831]
  Authors
Pastuszak I, Drake R, Elbein AD.
  Title
Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.
  Journal
J. Biol. Chem. 271 (1996) 20776-82.
  Organism
Sus scofa
Reference
2  [PMID:8798585]
  Authors
Pastuszak I, O'Donnell J, Elbein AD.
  Title
Identification of the GalNAc kinase amino acid sequence.
  Journal
J. Biol. Chem. 271 (1996) 23653-6.
  Organism
Homo sapiens, Sus scofa
  Sequence
[up:Q01415]
Reference
3  [PMID:16006554]
  Authors
Thoden JB, Holden HM.
  Title
The molecular architecture of human N-acetyl galactosamine kinase.
  Journal
J. Biol. Chem.  (2005) .
  Organism
Homo sapiens
  Sequence
[up:Q01415]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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