KEGG   ENZYME: 2.7.1.157Help
Entry
EC 2.7.1.157                Enzyme                                 

Name
N-acetylgalactosamine kinase;
GALK2;
GK2;
GalNAc kinase;
N-acetylgalactosamine (GalNAc)-1-phosphate kinase;
ATP:N-acetyl-D-galactosamine 1-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:N-acetyl-alpha-D-galactosamine 1-phosphotransferase
Reaction(IUBMB)
ATP + N-acetyl-alpha-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate [RN:R08967]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-alpha-D-galactosamine
Product
ADP [CPD:C00008];
N-acetyl-alpha-D-galactosamine 1-phosphate [CPD:C18060]
Comment
The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.
History
EC 2.7.1.157 created 2005
Orthology
K18674  
N-acetylgalactosamine kinase
Genes
HSA: 
2585(GALK2)
PTR: 
744911(GALK2)
PPS: 
100993695(GALK2)
GGO: 
101128070(GALK2)
PON: 
100173519(GALK2)
NLE: 
100580277(GALK2)
MCC: 
714866(GALK2)
MCF: 
102133835(GALK2)
CJC: 
MMU: 
69976(Galk2)
RNO: 
296117(Galk2)
CGE: 
100752083(Galk2)
NGI: 
103733040(Galk2)
HGL: 
101714414(Galk2)
OCU: 
100349778(GALK2)
TUP: 
102477172(GALK2)
CFA: 
487548(GALK2)
AML: 
100474626(GALK2)
UMR: 
103676726(GALK2)
FCA: 
101097562(GALK2)
PTG: 
102956946(GALK2)
BTA: 
536133(GALK2)
BOM: 
102285422(GALK2)
PHD: 
102324705(GALK2)
CHX: 
102177984(GALK2)
OAS: 
101108754(GALK2)
SSC: 
100152312(GALK2)
CFR: 
102518566(GALK2)
BACU: 
103019442(GALK2)
LVE: 
103086640(GALK2)
ECB: 
100070040(GALK2)
MYB: 
102261265(GALK2)
MYD: 
102759909(GALK2)
PALE: 
102887362(GALK2)
MDO: 
100025887(GALK2)
SHR: 
100927973(GALK2)
OAA: 
GGA: 
415596(GALK2)
MGP: 
100541570(GALK2)
APLA: 
101800821(GALK2)
TGU: 
100220666(GALK2)
FAB: 
101809065(GALK2)
PHI: 
102104028(GALK2)
FPG: 
101914646(GALK2)
FCH: 
102056200(GALK2)
CLV: 
102088209(GALK2)
ASN: 
102386197(GALK2)
AMJ: 
102566502(GALK2)
PSS: 
102462792(GALK2)
CMY: 
102935480(GALK2)
ACS: 
100560349(galk2)
PBI: 
103054405(GALK2)
XLA: 
380379(galk2)
XTR: 
448280(galk2)
DRE: 
792268(galk2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102351584(GALK2)
CMK: 
103186962(galk2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551581(GB12997)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_M01D7.4(tag-96)
CBR: 
CBG22217(Cbr-tag-96)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT3G06580(GALK)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0008s10240g(POPTRDRAFT_820551) POPTR_0010s15800g(POPTRDRAFT_723945)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os03t0832600-01(Os03g0832600)
OBR: 
BDI: 
SBI: 
SORBI_01g002480(SORBIDRAFT_01g002480)
ZMA: 
100284953(pco060326)
SITA: 
PDA: 
ATR: 
s00003p00233980(AMTR_s00003p00233980)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
CCP: 
LBC: 
DDI: 
DPP: 
DFA: 
DFA_05675(galK)
ACAN: 
TGO: 
TET: 
PTM: 
PIF: 
GTT: 
TVA: 
SACI: 
 » show all
Taxonomy
Reference
1  [PMID:8702831]
  Authors
Pastuszak I, Drake R, Elbein AD.
  Title
Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.
  Journal
J. Biol. Chem. 271 (1996) 20776-82.
Reference
2  [PMID:8798585]
  Authors
Pastuszak I, O'Donnell J, Elbein AD.
  Title
Identification of the GalNAc kinase amino acid sequence.
  Journal
J. Biol. Chem. 271 (1996) 23653-6.
  Sequence
[hsa:2585]
Reference
3  [PMID:16006554]
  Authors
Thoden JB, Holden HM.
  Title
The molecular architecture of human N-acetyl galactosamine kinase.
  Journal
J. Biol. Chem.  (2005) .
  Sequence
[hsa:2585]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system