KEGG   ENZYME: 2.7.1.158Help
Entry
EC 2.7.1.158                Enzyme                                 

Name
inositol-pentakisphosphate 2-kinase;
IP5 2-kinase;
Gsl1p;
Ipk1p;
inositol polyphosphate kinase;
inositol 1,3,4,5,6-pentakisphosphate 2-kinase;
Ins(1,3,4,5,6)P5 2-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase
Reaction(IUBMB)
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate [RN:R05202]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Product
ADP [CPD:C00008];
1D-myo-inositol hexakisphosphate [CPD:C01204]
Comment
The enzyme can also use Ins(1,4,5,6)P4 [2] and Ins(1,4,5)P3 [3] as substrate. Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolysed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment [5].
History
EC 2.7.1.158 created 2006
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K10572  
inositol-pentakisphosphate 2-kinase
Genes
HSA: 
64768(IPPK)
PTR: 
740083(IPPK)
PPS: 
GGO: 
101146670(IPPK)
PON: 
100445346(IPPK)
MCC: 
705937(IPPK)
MCF: 
102125417(IPPK)
MMU: 
75678(Ippk)
RNO: 
306808(Ippk)
CGE: 
100755765(Ippk)
HGL: 
101698360(Ippk)
TUP: 
102501070(IPPK)
CFA: 
484215(IPPK)
AML: 
100472139(IPPK)
FCA: 
101083117(IPPK)
PTG: 
102954516(IPPK)
BTA: 
521083(IPPK)
BOM: 
102279192(IPPK)
PHD: 
102322548(IPPK)
CHX: 
102189953(IPPK)
OAS: 
101107928(IPPK)
SSC: 
100514040(IPPK)
CFR: 
102507284(IPPK)
BACU: 
103006293(IPPK)
LVE: 
103081103(IPPK)
ECB: 
100055987(IPPK)
MYB: 
102248998(IPPK)
MYD: 
102761154(IPPK)
PALE: 
102882841(IPPK)
MDO: 
OAA: 
GGA: 
415951(IPPK)
MGP: 
100539260(IPPK)
TGU: 
100232713(IPPK)
FAB: 
101814368(IPPK)
PHI: 
102102622(IPPK)
APLA: 
101797545(IPPK)
FPG: 
101918249(IPPK)
FCH: 
102058004(IPPK)
CLV: 
102089388(IPPK)
ASN: 
102367780(IPPK)
AMJ: 
102560753(IPPK)
PSS: 
102449945(IPPK)
CMY: 
102944728(IPPK)
ACS: 
100554094(ippk)
PBI: 
103059819(IPPK)
XTR: 
780205(ippk)
DRE: 
541511(ippk)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102365442(IPPK)
CMK: 
103188780(ippk)
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
TCA: 
ISC: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
POP: 
POPTR_0002s03430g(POPTRDRAFT_1071163) POPTR_0005s25180g(POPTRDRAFT_818753)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os04t0661200-01(Os04g0661200)
OBR: 
BDI: 
ZMA: 
100125652(ipp2K) 100126363(cl9911_2) 100501721
SITA: 
ATR: 
s00011p00177280(AMTR_s00011p00177280)
SMO: 
PPP: 
OLU: 
OTA: 
MIS: 
MPP: 
CVR: 
GSL: 
CCP: 
TMS: 
DSQ: 
SHS: 
PCO: 
PSQ: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT35200(AGABI1DRAFT_35200)
ABV: 
AGABI2DRAFT63616(AGABI2DRAFT_63616)
CPUT: 
SLA: 
PFP: 
PGR: 
MLR: 
DDI: 
DPP: 
DFA: 
ACAN: 
TPS: 
PIF: 
NGD: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:10390371]
  Authors
York JD, Odom AR, Murphy R, Ives EB, Wente SR.
  Title
A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.
  Journal
Science. 285 (1999) 96-100.
  Sequence
[sce:YDR315C]
Reference
2  [PMID:7961779]
  Authors
Phillippy BQ, Ullah AH, Ehrlich KC.
  Title
Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds.
  Journal
J. Biol. Chem. 269 (1994) 28393-9.
Reference
3
  Authors
Phillippy, B.Q., Ullah, A.H. and Ehrlich, K.C.
  Title
Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds.
  Journal
J. Biol. Chem. 270 (1997) 7782.
Reference
4  [PMID:9794810]
  Authors
Ongusaha PP, Hughes PJ, Davey J, Michell RH.
  Title
Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.
  Journal
Biochem. J. 335 ( Pt 3) (1998) 671-9.
Reference
5  [PMID:15459192]
  Authors
Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR.
  Title
Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway.
  Journal
J. Biol. Chem. 279 (2004) 51022-32.
Reference
6  [PMID:12226109]
  Authors
Stevenson-Paulik J, Odom AR, York JD.
  Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
  Journal
J. Biol. Chem. 277 (2002) 42711-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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