KEGG   ENZYME: 2.7.1.164Help
Entry
EC 2.7.1.164                Enzyme                                 
Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]
Product
ADP [CPD:C00008];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
Pathway
Selenocompound metabolism
Aminoacyl-tRNA biosynthesis
Orthology
K10837  
O-phosphoseryl-tRNA(Sec) kinase
Genes
HSA: 
118672(PSTK)
PTR: 
466225(PSTK)
PPS: 
100991616(PSTK)
GGO: 
101132103(PSTK)
PON: 
100444035(PSTK)
MCC: 
MMU: 
214580(Pstk)
RNO: 
361661(RGD1564300)
CFA: 
477855(PSTK)
AML: 
FCA: 
101097176(PSTK)
BTA: 
511744(PSTK)
SSC: 
100517244
ECB: 
100050336
MDO: 
100025338
SHR: 
100928232(PSTK)
OAA: 
100087684
GGA: 
771778(PSTK)
MGP: 
100541977
ACS: 
100560637
XLA: 
444702(pstk)
XTR: 
100158568(pstk)
TRU: 
101079271
OLA: 
101163364
BFO: 
BRAFLDRAFT_96898
CIN: 
100177473
SPU: 
100888397
DME: 
Dmel_CG12788
DPO: 
Dpse_GA22688
DAN: 
Dana_GF20280
DER: 
Dere_GG18044
DPE: 
Dper_GL27106
DSE: 
Dsec_GM22728
DYA: 
Dyak_GE17373
DGR: 
Dgri_GH24035
DMO: 
Dmoj_GI11009
DVI: 
Dvir_GJ15608
AAG: 
AaeL_AAEL002489
CQU: 
CpipJ_CPIJ010839
PHU: 
Phum_PHUM297960
ISC: 
IscW_ISCW010109
TSP: 
Tsp_10561
SMM: 
Smp_074770
NVE: 
NEMVE_v1g212045
HMG: 
100200454
TAD: 
TRIADDRAFT_58609
AQU: 
100632695
CRE: 
CHLREDRAFT_206160(PSK1)
OTA: 
Ot09g01870
NGR: 
NAEGRDRAFT_78247(FM175)
DDI: 
DDB_G0286469
DPP: 
DICPUDRAFT_156071
PTI: 
PHATRDRAFT_41418
MJA: 
MJ_1538
MFE: 
Mefer_1539
MVU: 
Metvu_0654
MFS: 
MFS40622_0749
MIF: 
Metin_1012
MIG: 
Metig_0165
MMP: 
MMP1490
MMQ: 
MmarC5_0087
MMX: 
MmarC6_1184
MMZ: 
MmarC7_0734
MMD: 
GYY_08290
MAE: 
Maeo_0491
MVN: 
Mevan_0799
MVO: 
Mvol_1610
MOK: 
Metok_1516
MKA: 
MK1679
 » show all
Taxonomy
Reference
1  [PMID:15317934]
  Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
  Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 12848-53.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Caenorhabditis elegans [GN:cel], Methanococcus jannaschii [GN:mja], Methanopyrus kandleri [GN:mka]
Reference
2  [PMID:18174226]
  Authors
Sherrer RL, O'Donoghue P, Soll D
  Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
  Journal
Nucleic. Acids. Res. 36 (2008) 1247-59.
  Organism
Methanococcus jannaschii [GN:mja]
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry. 37 (1998) 3518-28.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
91273-83-5
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