KEGG   ENZYME: 2.7.1.164Help
Entry
EC 2.7.1.164                Enzyme                                 

Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]
Product
ADP [CPD:C00008];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
History
EC 2.7.1.164 created 2009
Pathway
Selenocompound metabolism
Aminoacyl-tRNA biosynthesis
Orthology
K10837  
O-phosphoseryl-tRNA(Sec) kinase
Genes
HSA: 
118672(PSTK)
PTR: 
466225(PSTK)
PPS: 
100991616(PSTK)
GGO: 
101132103(PSTK)
PON: 
100444035(PSTK)
NLE: 
100604256(PSTK)
MCC: 
CJC: 
100395731(PSTK)
MMU: 
214580(Pstk)
RNO: 
361661(Pstk)
CGE: 
100766247(Pstk)
HGL: 
101700708(Pstk)
TUP: 
102495932(PSTK)
CFA: 
477855(PSTK)
AML: 
FCA: 
101097176(PSTK)
PTG: 
102952756(PSTK)
BTA: 
511744(PSTK)
BOM: 
102266938(PSTK)
PHD: 
102335060(PSTK)
CHX: 
102176662(PSTK)
OAS: 
101113029(PSTK)
SSC: 
100517244(PSTK)
CFR: 
102516976(PSTK)
BACU: 
LVE: 
103077611(PSTK)
ECB: 
100050336(PSTK)
MYB: 
102256958(PSTK)
MYD: 
102770046(PSTK)
PALE: 
102883394(PSTK)
MDO: 
100025338(PSTK)
SHR: 
100928232(PSTK)
OAA: 
100087684(PSTK)
GGA: 
771778(PSTK)
MGP: 
APLA: 
101795083(PSTK)
FAB: 
101818121(PSTK)
PHI: 
102100740(PSTK)
FPG: 
101917794(PSTK)
FCH: 
102057982(PSTK)
CLV: 
102096798(PSTK)
ASN: 
102369560(PSTK)
AMJ: 
102576845(PSTK)
PSS: 
102452198(PSTK)
CMY: 
102937930(PSTK)
ACS: 
100560637(pstk)
PBI: 
103065614(PSTK)
XLA: 
444702(pstk)
XTR: 
100158568(pstk)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102366882(PSTK)
CMK: 
103185460(pstk)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DYA: 
DGR: 
DMO: 
DVI: 
AAG: 
CQU: 
PHU: 
ISC: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CRE: 
OLU: 
OTA: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
DDI: 
DFA: 
ACAN: 
PTI: 
PIF: 
EHX: 
GTT: 
NGR: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MJH: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MKA: 
 » show all
Taxonomy
Reference
1  [PMID:15317934]
  Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
  Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 12848-53.
  Sequence
[mmu:214580]
Reference
2  [PMID:18174226]
  Authors
Sherrer RL, O'Donoghue P, Soll D
  Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
  Journal
Nucleic. Acids. Res. 36 (2008) 1247-59.
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry. 37 (1998) 3518-28.
  Sequence
[up:P07658]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
91273-83-5

DBGET integrated database retrieval system