KEGG   ENZYME: 2.7.1.169Help
Entry
EC 2.7.1.169                Enzyme                                 

Name
pantoate kinase;
PoK;
TK2141 protein
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(R)-pantoate 4-phosphotransferase
Reaction(IUBMB)
ATP + (R)-pantoate = ADP + (R)-4-phosphopantoate [RN:R09378]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-pantoate [CPD:C00522]
Product
ADP [CPD:C00008];
(R)-4-phosphopantoate [CPD:C18911]
Comment
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
History
EC 2.7.1.169 created 2011
Pathway
Pantothenate and CoA biosynthesis
Metabolic pathways
Orthology
K06982  
pantoate kinase
Genes
SSM: 
STA: 
STQ: 
SRU: 
SRM: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MMA: 
MMAZ: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
MER: 
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
mru_1010(coaA)
MEB: 
Abm4_0658(coaA)
MEL: 
MEW: 
METH: 
MFV: 
MKA: 
MAX: 
AFU: 
APO: 
AVE: 
AST: 
FPL: 
HAL: 
HSL: 
OE1396R(kin2)
HMA: 
HHI: 
HHN: 
HWA: 
HQ1271A(kin)
HWC: 
NPH: 
NMO: 
HLA: 
HUT: 
HTI: 
HMU: 
HTU: 
NMG: 
HVO: 
HME: 
HJE: 
HBO: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
TAR: 
PHO: 
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
ABI: 
ACF: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
SSO: 
SOL: 
STO: 
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
TPE: 
THB: 
ASC: 
CLG: 
FFO: 
NMR: 
NIR: 
NKR: 
CSY: 
NGA: 
CSU: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:19666462]
  Authors
Yokooji Y, Tomita H, Atomi H, Imanaka T
  Title
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.
  Journal
J. Biol. Chem. 284 (2009) 28137-45.
  Organism
Thermococcus kodakarensis [GN:tko]
  Sequence
[tko:TK2141]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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