KEGG   ENZYME: 2.7.1.171Help
Entry
EC 2.7.1.171                Enzyme                                 

Name
protein-fructosamine 3-kinase;
FN3K;
fructosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:[protein]-N6-D-fructosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-fructosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-fructosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine
Comment
Non-enzymic glycation is an important factor in the pathogenesis of diabetic complications. Key early intermediates in this process are fructosamines, such as [protein]-N6-D-fructosyl-L-lysine. Fructosamine-3-kinase is part of an ATP-dependent system for removing carbohydrates from non-enzymically glycated proteins. The phosphorylation destablilizes the [protein]-N6-D-fructosyl-L-lysine adduct and leads to its spontaneous decomposition. cf. EC 2.7.1.172, protein-ribulosamine 3-kinase.
History
EC 2.7.1.171 created 2011
Orthology
K15522  
protein-fructosamine 3-kinase
Genes
HSA: 
64122(FN3K)
PTR: 
454999(FN3K)
PPS: 
100983475(FN3K)
GGO: 
101129274(FN3K)
PON: 
100432964(FN3K)
NLE: 
100601146(FN3K)
MCC: 
106994166(FN3K)
MCF: 
102132233(FN3K)
CJC: 
100397627(FN3K)
MMU: 
63828(Fn3k)
RNO: 
498034(Fn3k)
CGE: 
100751771(Fn3k)
NGI: 
103739318(Fn3k)
HGL: 
101712216(Fn3k)
OCU: 
100346330(FN3K)
TUP: 
102490564(FN3K)
CFA: 
608337(FN3K)
AML: 
100466189(FN3K)
UMR: 
103666019(FN3K)
FCA: 
101093222(FN3K)
PTG: 
102972520(FN3K)
BTA: 
539709(FN3K)
BOM: 
102280823(FN3K)
PHD: 
102343329(FN3K)
CHX: 
102184090(FN3K)
OAS: 
101108403(FN3K)
SSC: 
100523990(FN3K)
CFR: 
102524293(FN3K)
LVE: 
103083772(FN3K)
ECB: 
100056532(FN3K)
MYB: 
102254271(FN3K)
MYD: 
102773280(FN3K)
PALE: 
102898341(FN3K)
OAA: 
100079558(FN3K)
GGA: 
417335(FN3K)
MGP: 
100547749(FN3K)
APLA: 
101790399(FN3K)
TGU: 
100226491(FN3K)
GFR: 
102032280(FN3K)
FAB: 
101809933(FN3K)
PHI: 
102111398(FN3K)
CCW: 
104695651(FN3K)
FPG: 
101910565(FN3K)
FCH: 
102059933(FN3K)
CLV: 
102083783(FN3K)
ASN: 
102371989(FN3K)
AMJ: 
102571431(FN3K)
PSS: 
102448713(FN3K)
CMY: 
102934080(FN3K)
ACS: 
PBI: 
103060185(FN3K)
OBI: 
NGD: 
 » show all
Taxonomy
Reference
1  [PMID:11522682]
  Authors
Szwergold BS, Howell S, Beisswenger PJ
  Title
Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo.
  Journal
Diabetes. 50 (2001) 2139-47.
  Sequence
[hsa:64122]
Reference
2  [PMID:11016445]
  Authors
Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E
  Title
Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.
  Journal
Diabetes. 49 (2000) 1627-34.
  Sequence
[hsa:64122] [mmu:63828]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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