KEGG   ENZYME: 2.7.1.172Help
Entry
EC 2.7.1.172                Enzyme                                 

Name
protein-ribulosamine 3-kinase;
Fn3KRP;
FN3K-related protein;
FN3K-RP;
ketosamine 3-kinase 2;
fructosamine-3-kinase-related protein;
ribulosamine/erythrulosamine 3-kinase;
ribulosamine 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:[protein]-N6-D-ribulosyl-L-lysine 3-phosphotransferase
Reaction(IUBMB)
ATP + [protein]-N6-D-ribulosyl-L-lysine = ADP + [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
Substrate
ATP [CPD:C00002];
[protein]-N6-D-ribulosyl-L-lysine
Product
ADP [CPD:C00008];
[protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine
Comment
This enzyme plays a role in freeing proteins from ribulosamines or psicosamines, which might arise from the reaction of amines with glucose and/or glycolytic intermediates. This role is shared by EC 2.7.1.171 (protein-fructosamine 3-kinase), which has, in addition, the unique capacity to phosphorylate fructosamines [1]. The plant enzyme also phosphorylates [protein]-N6-D-erythrulosyl-L-lysine [2]. No activity with [protein]-N6-D-fructosyl-L-lysine [1,2].
History
EC 2.7.1.172 created 2011
Orthology
K15523  
protein-ribulosamine 3-kinase
Genes
HSA: 
79672(FN3KRP)
PTR: 
468364(FN3KRP)
PPS: 
100982920(FN3KRP)
GGO: 
101128927(FN3KRP)
PON: 
100173348(FN3KRP)
NLE: 
100598556(FN3KRP)
MCC: 
716431(FN3KRP)
MCF: 
101926623(FN3KRP)
CSAB: 
103243781(FN3KRP)
RRO: 
CJC: 
103793436(FN3KRP)
SBQ: 
101053544(FN3KRP)
MMU: 
238024(Fn3krp)
RNO: 
303755(Fn3krp)
CGE: 
100752057(Fn3krp)
NGI: 
103739319(Fn3krp)
HGL: 
101709333(Fn3krp)
OCU: 
100344530(FN3KRP)
TUP: 
102476157(FN3KRP)
CFA: 
480821(FN3KRP)
AML: 
100464438(FN3KRP)
UMR: 
103666018(FN3KRP)
FCA: 
101092971(FN3KRP)
PTG: 
102972037(FN3KRP)
BTA: 
615868(FN3KRP)
BOM: 
102281298(FN3KRP)
PHD: 
102342977(FN3KRP)
CHX: 
102184372(FN3KRP)
OAS: 
101108669(FN3KRP)
SSC: 
100523691(FN3KRP)
CFR: 
102524558(FN3KRP)
BACU: 
102998458(FN3K)
LVE: 
103084046(FN3KRP)
ECB: 
100056107(FN3KRP)
MYB: 
102243427(FN3KRP)
MYD: 
102772995(FN3KRP)
PALE: 
102898584(FN3KRP)
LAV: 
100670171(FN3KRP)
MDO: 
100020750(FN3KRP)
SHR: 
100913340(FN3KRP)
OAA: 
100079591(FN3KRP)
GGA: 
417336(FN3KRP)
MGP: 
100550464(FN3KRP)
CJO: 
APLA: 
101792751(FN3KRP)
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
101910739(FN3KRP)
FCH: 
102060101(FN3KRP)
CLV: 
102083608(FN3KRP)
AAM: 
ASN: 
102375382(FN3KRP)
AMJ: 
102571809(FN3KRP)
PSS: 
102458928(FN3KRP)
CMY: 
102934304(FN3KRP)
ACS: 
100552114(fn3krp)
PBI: 
103055928(FN3KRP)
GJA: 
107121874(FN3KRP)
XLA: 
444726(fn3k)
XTR: 
779663(fn3krp)
DRE: 
559954(fn3krp)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
102228035(fn3krp)
SASA: 
LCM: 
102361196(FN3KRP)
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_Y116A8C.25(Y116A8C.25)
BMY: 
LOA: 
LGI: 
NVE: 
ADF: 
AQU: 
 » show all
Taxonomy
Reference
1  [PMID:14633848]
  Authors
Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E
  Title
A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase  acting on psicosamines and ribulosamines but not on fructosamines.
  Journal
Diabetes. 52 (2003) 2888-95.
  Sequence
[hsa:79672] [mmu:238024]
Reference
2  [PMID:15705060]
  Authors
Fortpied J, Gemayel R, Stroobant V, van Schaftingen E
  Title
Plant ribulosamine/erythrulosamine 3-kinase, a putative protein-repair enzyme.
  Journal
Biochem. J. 388 (2005) 795-802.
  Sequence
[ath:AT3G61080] [osa:4331411]
Reference
3  [PMID:18637789]
  Authors
Payne LS, Brown PM, Middleditch M, Baker E, Cooper GJ, Loomes KM
  Title
Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein  by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine.
  Journal
Biochem. J. 416 (2008) 281-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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