KEGG   ENZYME: 2.7.1.174Help
Entry
EC 2.7.1.174                Enzyme                                 

Name
diacylglycerol kinase (CTP);
DAG kinase;
CTP-dependent diacylglycerol kinase;
diglyceride kinase (ambiguous);
DGK1 (gene name);
diacylglycerol kinase (CTP dependent)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
CTP:1,2-diacyl-sn-glycerol 3-phosphotransferase
Reaction(IUBMB)
CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate [RN:R09944]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
CDP [CPD:C00112];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]
Comment
Requires Ca2+ or Mg2+ for activity. Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Unlike the diacylglycerol kinases from bacteria, plants, and animals [cf. EC 2.7.1.107, diacylglycerol kinase (ATP)], the enzyme from Saccharomyces cerevisiae utilizes CTP. The enzyme can also use dCTP, but not ATP, GTP or UTP.
History
EC 2.7.1.174 created 2012, modified 2013
Pathway
Glycerophospholipid metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K16368  
diacylglycerol kinase (CTP)
Genes
MIS: 
SCE: 
YOR311C(DGK1)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B00880(NCAS0B00880)
NDI: 
NDAI_0E00540(NDAI0E00540)
TPF: 
TPHA_0G01150(TPHA0G01150)
TBL: 
TBLA_0B02820(TBLA0B02820) TBLA_0D00720(TBLA0D00720)
TDL: 
TDEL_0B01100(TDEL0B01100)
KAF: 
KAFR_0D01590(KAFR0D01590)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CAALFM_C200790CA(CaO19.2045)
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
CAUR: 
NCR: 
NTE: 
NEUTE1DRAFT84553(NEUTE1DRAFT_84553)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_1410194(AO090012000806)
ANG: 
ANI_1_1322024(An02g09160)
AFV: 
ACT: 
NFI: 
PCS: 
PDP: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT116813(AGABI1DRAFT_116813)
ABV: 
AGABI2DRAFT195012(AGABI2DRAFT_195012)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
PGR: 
MLR: 
ACAN: 
TET: 
PIF: 
PSOJ: 
SPAR: 
GTT: 
 » show all
Taxonomy
Reference
1  [PMID:18458075]
  Authors
Han GS, O'Hara L, Carman GM, Siniossoglou S
  Title
An unconventional diacylglycerol kinase that regulates phospholipid synthesis and nuclear membrane growth.
  Journal
J. Biol. Chem. 283 (2008) 20433-42.
  Sequence
[sce:YOR311C]
Reference
2  [PMID:18458076]
  Authors
Han GS, O'Hara L, Siniossoglou S, Carman GM
  Title
Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase.
  Journal
J. Biol. Chem. 283 (2008) 20443-53.
  Sequence
[sce:YOR311C]
Reference
3  [PMID:21071438]
  Authors
Fakas S, Konstantinou C, Carman GM
  Title
DGK1-encoded diacylglycerol kinase activity is required for phospholipid synthesis during growth resumption from stationary phase in Saccharomyces cerevisiae.
  Journal
J. Biol. Chem. 286 (2011) 1464-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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