KEGG   ENZYME: 2.7.1.176Help
Entry
EC 2.7.1.176                Enzyme                                 

Name
UDP-N-acetylglucosamine kinase;
UNAG kinase;
zeta toxin;
toxin PezT;
ATP:UDP-N-acetyl-D-glucosamine 3'-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:UDP-N-acetyl-alpha-D-glucosamine 3'-phosphotransferase
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [RN:R09946]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043]
Product
ADP [CPD:C00008];
UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate [CPD:C20245]
Comment
Toxic component of a toxin-antitoxin (TA) module. The phosphorylation of UDP-N-acetyl-D-glucosamine results in the inhibition of EC 2.5.1.7, UDP-N-acetylglucosamine 1-carboxyvinyltransferase, the first committed step in cell wall synthesis, which is then blocked. The activity of this enzyme is inhibited when the enzyme binds to the cognate epsilon antitoxin.
History
EC 2.7.1.176 created 2012
Orthology
K16214  
UDP-N-acetylglucosamine kinase
Genes
HAP: 
HPAS: 
HPAK: 
MVR: 
AAO: 
GAN: 
SPN: 
SPD: 
SPR: 
SPW: 
SPX: 
SNE: 
SPV: 
SNM: 
SJJ: 
SPP: 
SNB: 
SNV: 
SNX: 
SNU: 
SPNG: 
SPNE: 
SPNU: 
SPNM: 
SPNO: 
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STU: 
SSU: 
SSV: 
SSB: 
SSS: 
SSK: 
SSQ: 
SUI: 
SUO: 
SSUS: 
SEZO: 
SEQU: 
SMB: 
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SIU: 
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SOI: 
SIG: 
EFL: 
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EFN: 
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GVG: 
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ELE: 
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 » show all
Taxonomy
Reference
1  [PMID:17488720]
  Authors
Khoo SK, Loll B, Chan WT, Shoeman RL, Ngoo L, Yeo CC, Meinhart A
  Title
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae.
  Journal
J. Biol. Chem. 282 (2007) 19606-18.
  Sequence
[spn:SP_1051]
Reference
2  [PMID:21445328]
  Authors
Mutschler H, Gebhardt M, Shoeman RL, Meinhart A
  Title
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis.
  Journal
PLoS. Biol. 9 (2011) e1001033.
  Sequence
[spn:SP_1051]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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