KEGG   ENZYME: 2.7.1.177Help
Entry
EC 2.7.1.177                Enzyme                                 

Name
L-threonine kinase;
PduX
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:L-threonine O3-phosphotransferase
Reaction(IUBMB)
ATP + L-threonine = ADP + O-phospho-L-threonine [RN:R06531]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
L-threonine [CPD:C00188]
Product
ADP [CPD:C00008];
O-phospho-L-threonine [CPD:C12147]
Comment
The enzyme is involved in the de novo synthesis of adenosylcobalamin. It is specific for ATP and free L-threonine. In the bacterium Salmonella enterica the activity with CTP, GTP, or UTP is 6, 11, and 3% of the activity with ATP.
History
EC 2.7.1.177 created 2012
Pathway
ec00860  Porphyrin and chlorophyll metabolism
Orthology
K16651  L-threonine kinase
Genes
STY: STY2263(pduX)
STT: t0816(pduX)
SEX: STBHUCCB_8710
SENT: TY21A_04145
STM: STM2058(pduX)
SEO: STM14_2547(pduX)
SEV: STMMW_20881
SEY: SL1344_2034(pduX)
SEM: STMDT12_C20800
SEJ: STMUK_2088(pduX)
SEB: STM474_2143(pduX)
SEF: UMN798_2224(pduX)
SENR: STMDT2_20311(pduX)
SEND: DT104_21151(pduX)
SENI: CY43_11105
SPT: SPA0813(pduX)
SEK: SSPA0760
SEI: SPC_1656(pduX)
SEC: SCH_2067(pduX)
SHB: SU5_02652
SENS: Q786_10160
SED: SeD_A2394
SEG: SG2087(pduX)
SEL: SPUL_0842(pduX)
SEGA: SPUCDC_0842(pduX)
SET: SEN2056(pduX)
SENA: AU38_10375
SENO: AU37_10385
SENV: AU39_10385
SENQ: AU40_11630
SENL: IY59_10670
SEEP: I137_03795
SENE: IA1_10270
SBZ: A464_2182
ENF: AKI40_1785(pduX)
KPN: KPN_03223(pduX)
KPU: KP1_4492(pduX)
KPP: A79E_0887
KPE: KPK_0892(pduX)
KPR: KPR_1810(pduX)
KPJ: N559_1016
KPX: PMK1_00704(pduX)
KPNU: LI86_05020
KPNK: BN49_0885(pduX)
KVA: Kvar_0847
KOX: KOX_01545
KOE: A225_4774
CKO: CKO_00778
CRO: ROD_21441(pduX)
CAMA: F384_10500
EBF: D782_1619
YEN: YE2750(pduX) YE4039(pduX)
YEE: YE5303_31831(pduX) YE5303_38731(pduX)
YFR: AW19_699
YKR: CH54_963
YRO: CH64_1336
PLU: plu2966
PAY: PAU_01636(pduX)
XBO: XBJ1_0855
XBV: XBW1_1555
XNE: XNC1_1145
XNM: XNC2_1124
MMK: MU9_1018
ETR: ETAE_2006
ETD: ETAF_1814
ETE: ETEE_4061(pduX)
GAI: IMCC3135_05635(pduX)
TAU: Tola_1706
BTM: MC28_E122
LMO: lmo1170
LMS: LMLG_1094
LMQ: LMM7_1176(pduX)
LML: lmo4a_1153(pduX)
LMP: MUO_06045
LMW: LMOSLCC2755_1162(pduX)
LMX: LMOSLCC2372_1165(pduX)
LMZ: LMOSLCC2482_1209(pduX)
LMON: LMOSLCC2376_1121(pduX)
LMOC: LMOSLCC5850_1159(pduX)
LMOS: LMOSLCC7179_1137(pduX)
LMOO: LMOSLCC2378_1175(pduX)
LMOY: LMOSLCC2479_1166(pduX)
LMOT: LMOSLCC2540_1148(pduX)
LMOA: LMOATCC19117_1170(pduX)
LMOL: LMOL312_1157(pduX)
LMOE: BN418_1373
LMOB: BN419_1371
LMOD: LMON_1163
LMOW: AX10_14355
LMOX: AX24_03220
LMOK: CQ02_06015
LMOM: IJ09_04485
LIN: lin1134
LWE: lwe1128
LSG: lse_1048(pduX)
LIV: LIV_1102
SSA: SSA_0511(pduX)
CAC: CA_C1371
CAE: SMB_G1394
CAY: CEA_G1385
CTC: CTC_00786
CBO: CBO0953(pduX)
CBA: CLB_0995
CBH: CLC_1009
CBY: CLM_1104
CBL: CLK_0391
CBB: CLD_3607
CBI: CLJ_B1004
CBF: CLI_1043
CBM: CBF_1012
CKL: CKL_0717
CKR: CKR_0639
CPAS: Clopa_1225
CPAT: CLPA_c12730(pduX)
CPAE: CPAST_c12730(pduX)
CSQ: CSCA_5077
CACE: CACET_c00560(pduX)
CTYK: CTK_C09530
AMT: Amet_0068
PDC: CDIF630_03739(pduX)
CST: CLOST_0986(pduX)
DSY: DSY4058
DHD: Dhaf_1308
DRM: Dred_2702
HMO: HM1_2403
ELM: ELI_0756
TKI: TKV_c19670(pduX)
CHY: CHY_0772
MTA: Moth_1103
TPZ: Tph_c05150(pduX)
TOC: Toce_1423
VPR: Vpar_0909
MED: MELS_1829
MHG: MHY_16040
PUF: UFO1_2208
PFT: JBW_02349
LPIL: LIP_3518
TLI: Tlie_0163
 » show all
Taxonomy
Reference
1  [PMID:18308727]
  Authors
Fan C, Bobik TA.
  Title
The PduX enzyme of Salmonella enterica is an L-threonine kinase used for coenzyme B12 synthesis.
  Journal
J. Biol. Chem. 283 (2008) 11322-9.
  Sequence
[stm:STM2058]
Reference
2  [PMID:19509296]
  Authors
Fan C, Fromm HJ, Bobik TA.
  Title
Kinetic and functional analysis of L-threonine kinase, the PduX enzyme of Salmonella enterica.
  Journal
J. Biol. Chem. 284 (2009) 20240-8.
  Sequence
[stm:STM2058]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.177
IUBMB Enzyme Nomenclature: 2.7.1.177
ExPASy - ENZYME nomenclature database: 2.7.1.177
BRENDA, the Enzyme Database: 2.7.1.177

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