KEGG   ENZYME: 2.7.1.178Help
Entry
EC 2.7.1.178                Enzyme                                 

Name
2-dehydro-3-deoxyglucono/galactono-kinase;
KDG kinase (ambiguous);
KDGK (ambiguous);
2-keto-3-deoxy-D-gluconate kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase
Reaction(IUBMB)
(1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6-phospho-D-gluconate [RN:R01541];
(2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6-phospho-D-galactonate [RN:R03387]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2-dehydro-3-deoxy-D-gluconate [CPD:C00204];
2-dehydro-3-deoxy-D-galactonate [CPD:C01216]
Product
ADP [CPD:C00008];
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:C04442];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:C01286]
Comment
The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with similar catalytic efficiency. cf. EC 2.7.1.45, 2-dehydro-3-deoxygluconokinase and EC 2.7.1.58, 2-dehydro-3-deoxygalactonokinase.
History
EC 2.7.1.178 created 2013
Pathway
Pentose phosphate pathway
Galactose metabolism
Metabolic pathways
Orthology
K18126  
2-dehydro-3-deoxygluconokinase / 2-dehydro-3-deoxygalactonokinase
Genes
SSO: 
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
STK_24780(kdgK)
SAI: 
Saci_0226(kdgK)
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
PYR: 
CMA: 
TUZ: 
TTN: 
TTX_1157(kdgK)
VDI: 
VMO: 
CSU: 
 » show all
Taxonomy
Reference
1  [PMID:16330030]
  Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
  Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon  Sulfolobus solfataricus.
  Journal
FEBS. Lett. 579 (2005) 6865-9.
  Sequence
[sso:SSO3195]
Reference
2  [PMID:19018105]
  Authors
Potter JA, Kerou M, Lamble HJ, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structure of Sulfolobus solfataricus 2-keto-3-deoxygluconate kinase.
  Journal
Acta. Crystallogr. D. Biol. Crystallogr. 64 (2008) 1283-7.
  Sequence
[sso:SSO3195]
Reference
3  [PMID:16794308]
  Authors
Kim S, Lee SB
  Title
Characterization of Sulfolobus solfataricus 2-keto-3-deoxy-D-gluconate kinase in  the modified Entner-Doudoroff pathway.
  Journal
Biosci. Biotechnol. Biochem. 70 (2006) 1308-16.
  Sequence
[sso:SSO3195]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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