KEGG   ENZYME: 2.7.1.183Help
Entry
EC 2.7.1.183                Enzyme                                 

Name
glycoprotein-mannosyl O6-kinase;
SGK196;
protein O-mannose kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] 6-phosphotransferase
Reaction(IUBMB)
ATP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein] = ADP + O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
Substrate
ATP [CPD:C00002];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl/L-seryl-[protein]
Product
ADP [CPD:C00008];
O3-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-(6-phospho)mannosyl]-L-threonyl/L-seryl-[protein]
Comment
In humans this phosphorylated trisaccharide is attached to an L-threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and is important for its activity.
History
EC 2.7.1.183 created 2014
Orthology
K17547  
glycoprotein-mannosyl O6-kinase
Genes
HSA: 
84197(POMK)
PTR: 
464154(POMK)
PPS: 
100985143(POMK)
GGO: 
PON: 
100446965(POMK)
NLE: 
100593922(POMK)
MCC: 
706318(POMK)
MCF: 
102126456(POMK)
RRO: 
104668311(POMK)
CJC: 
100403123(POMK)
MMU: 
74653(Pomk)
RNO: 
306549(Pomk)
CGE: 
100771074(Pomk)
NGI: 
103728518(Pomk)
HGL: 
101699969(Pomk)
OCU: 
100346922(POMK)
TUP: 
102493452(POMK)
CFA: 
482834(POMK)
AML: 
100469245(POMK)
UMR: 
103677043(POMK)
FCA: 
102902090(POMK)
PTG: 
102958518(POMK)
BTA: 
514490(POMK)
BOM: 
102270881(POMK)
PHD: 
102332583(POMK)
CHX: 
102191304(POMK)
OAS: 
105605250(POMK)
BACU: 
103009793(POMK)
LVE: 
103085701(POMK)
ECB: 
100053457(POMK)
MYB: 
102242789(POMK)
MYD: 
102769516(POMK)
PALE: 
102890250(POMK)
MDO: 
100030275(POMK)
SHR: 
100924613(POMK)
OAA: 
100082420(POMK)
GGA: 
422491(SGK196)
MGP: 
100538885(POMK)
CJO: 
107313218(POMK)
APLA: 
101801929(POMK)
TGU: 
100231168(POMK)
GFR: 
102033758(POMK)
FAB: 
101811138(POMK)
PHI: 
102112849(POMK)
CCW: 
104697134(POMK)
FPG: 
101910645(POMK)
FCH: 
102059878(POMK)
CLV: 
102088245(POMK)
AAM: 
106484357(POMK)
ASN: 
102374161(POMK)
AMJ: 
102567007(POMK)
PSS: 
102445972(POMK)
CMY: 
ACS: 
100560387(pomk)
PBI: 
103068088(POMK)
GJA: 
107107431(POMK)
XLA: 
496338(pomk)
XTR: 
100497421(pomk)
DRE: 
492773(pomk)
TRU: 
MZE: 
101481202(pomk)
OLA: 
101164276(pomk)
XMA: 
106700026(pomk)
LCM: 
102349350(POMK)
CMK: 
103191503(pomk)
BFO: 
CIN: 
SKO: 
ISC: 
LGI: 
CRG: 
OBI: 
NVE: 
HMG: 
TAD: 
SRE: 
 » show all
Taxonomy
Reference
1  [PMID:23929950]
  Authors
Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
  Title
SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
  Journal
Science. 341 (2013) 896-9.
  Sequence
[hsa:84197]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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