KEGG   ENZYME: 2.7.1.185Help
Entry
EC 2.7.1.185                Enzyme                                 

Name
mevalonate 3-kinase;
ATP:(R)-MVA 3-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:(R)-mevalonate 3-phosphotransferase
Reaction(IUBMB)
ATP + (R)-mevalonate = ADP + (R)-3-phosphomevalonate [RN:R10779]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
(R)-mevalonate [CPD:C00418]
Product
ADP [CPD:C00008];
(R)-3-phosphomevalonate [CPD:C20847]
Comment
Mevalonate 3-kinase and mevalonate-3-phosphate-5-kinase (EC 2.7.1.186) act sequentially in an alternate mevalonate pathway in the archaeon Thermoplasma acidophilum. Mevalonate 3-kinase is different from mevalonate kinase, EC 2.7.1.36, which transfers phosphate to position 5 of (R)-mevalonate and is part of the classical mevalonate pathway in eukaryotes and archaea.
History
EC 2.7.1.185 created 2014
Pathway
Terpenoid backbone biosynthesis
Orthology
K18689  
mevalonate-3-kinase
Genes
TAC: 
TVO: 
PTO: 
FAC: 
Taxonomy
Reference
1  [PMID:24914732]
  Authors
Vinokur JM, Korman TP, Cao Z, Bowie JU.
  Title
Evidence of a novel mevalonate pathway in archaea.
  Journal
Biochemistry. 53 (2014) 4161-8.
  Sequence
[tac:Ta1305]
Reference
2  [PMID:24755225]
  Authors
Azami Y, Hattori A, Nishimura H, Kawaide H, Yoshimura T, Hemmi H.
  Title
(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum.
  Journal
J. Biol. Chem. 289 (2014) 15957-67.
  Sequence
[tac:Ta1305]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system