KEGG   ENZYME: 2.7.1.187Help
Entry
EC 2.7.1.187                Enzyme                                 

Name
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:acarbose 7IV-phosphotransferase
Reaction(IUBMB)
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
acarbose [CPD:C06802]
Product
ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
History
EC 2.7.1.187 created 2015
Pathway
Acarbose and validamycin biosynthesis
Orthology
K19978  
acarbose 7IV-phosphotransferase
Genes
SMA: 
SCB: 
SFA: 
SHY: 
SHO: 
SVE: 
SDV: 
STRP: 
SCI: 
SALU: 
SALL: 
SGU: 
STRE: 
SCW: 
SXI: 
SPRI: 
SCX: 
SRW: 
TUE45_07278(kdgK_4)
KSK: 
NDA: 
SRO: 
KAL: 
STP: 
ASE: 
AFS: 
CAI: 
SNA: 
 » show all
Taxonomy
Reference
1  [PMID:8784428]
  Authors
Drepper A, Pape H
  Title
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
  Journal
J. Antibiot. (Tokyo). 49 (1996) 664-8.
Reference
2  [PMID:8784426]
  Authors
Goeke K, Drepper A, Pape H
  Title
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
  Journal
J. Antibiot. (Tokyo). 49 (1996) 661-3.
Reference
3  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J. Biol. Chem. 277 (2002) 22853-62.
  Sequence
[ase:ACPL_3675]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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