KEGG   ENZYME: 2.7.1.188Help
Entry
EC 2.7.1.188                Enzyme                                 

Name
2-epi-5-epi-valiolone 7-kinase;
AcbM
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:2-epi-5-epi-valiolone 7-phosphotransferase
Reaction(IUBMB)
ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate [RN:R11185]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
2-epi-5-epi-valiolone [CPD:C17691]
Product
ADP [CPD:C00008];
2-epi-5-epi-valiolone 7-phosphate [CPD:C17692]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
History
EC 2.7.1.188 created 2015
Pathway
Acarbose and validamycin biosynthesis
Biosynthesis of antibiotics
Orthology
K19979  
2-epi-5-epi-valiolone 7-kinase
Genes
MUL: 
MMI: 
RER: 
REY: 
REB: 
RHB: 
SALS: 
SRW: 
AER: 
SESP: 
ASE: 
 » show all
Taxonomy
Reference
1  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J. Biol. Chem. 277 (2002) 22853-62.
  Sequence
[ase:ACPL_3676]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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