KEGG   ENZYME: 2.7.1.72Help
Entry
EC 2.7.1.72                 Enzyme                                 
Name
streptomycin 6-kinase;
streptidine kinase;
SM 6-kinase;
streptomycin 6-kinase (phosphorylating);
streptidine kinase (phosphorylating);
streptomycin 6-O-phosphotransferase;
streptomycin 6-phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:streptomycin 6-phosphotransferase
Reaction(IUBMB)
ATP + streptomycin = ADP + streptomycin 6-phosphate [RN:R02225]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
streptomycin [CPD:C00413]
Product
ADP [CPD:C00008];
streptomycin 6-phosphate [CPD:C01138]
Comment
dATP can replace ATP; and dihydrostreptomycin, streptidine and 2-deoxystreptidine can act as acceptors.
Pathway
Streptomycin biosynthesis
Orthology
K04343  
streptomycin 6-kinase
K12570  
streptomycin 6-kinase
Genes
MSM: 
MJL: 
RHA: 
SGR: 
SGR_5932(aphD)
AAU: 
Taxonomy
Reference
1  [PMID:4121456]
  Authors
Walker JB, Skorvaga M.
  Title
Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives.
  Journal
J. Biol. Chem. 248 (1973) 2435-40.
  Organism
Streptomyces griseus [GN:sgr]
Reference
2  [PMID:6075410]
  Authors
Walker JB, Walker MS.
  Title
Streptomycin biosynthesis. Enzymatic synthesis of O-phosphorylstreptidine from streptidine and adenosinetriphosphate.
  Journal
Biochim. Biophys. Acta. 148 (1967) 335-41.
  Organism
Streptomyces bikiniensis
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37278-11-8
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