KEGG   ENZYME: 2.7.11.16Help
Entry
EC 2.7.11.16                Enzyme                                 

Name
G-protein-coupled receptor kinase;
G protein-coupled receptor kinase;
GPCR kinase;
GPCRK;
GRK4;
GRK5;
GRK6;
STK16
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[G-protein-coupled receptor] phosphotransferase
Reaction(IUBMB)
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Substrate
ATP [CPD:C00002];
[G-protein-coupled receptor]
Product
ADP [CPD:C00008];
[G-protein-coupled receptor] phosphate
Comment
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, beta-adrenergic-receptor kinase).
History
EC 2.7.11.16 created 2005
Orthology
K08291  
G protein-coupled receptor kinase
Genes
HSA: 
2868(GRK4) 2869(GRK5) 2870(GRK6)
PTR: 
461082(GRK4) 466217(GRK5) 471760(GRK6)
PPS: 
100972068(GRK6) 100972921(GRK4) 100975050(GRK5)
GGO: 
101125204(GRK6) 101142802(GRK5) 101148767(GRK4)
PON: 
100171722(GRK5) 100433745(GRK6)
NLE: 
100592067(GRK6) 100593251(GRK5) 100595255(GRK4)
MCC: 
100427251(GRK5) 700000(GRK6) 720047(GRK4)
MCF: 
102115240(GRK4) 102128844(GRK6) 102132362(GRK5)
CSAB: 
103216606(GRK5) 103245054(GRK6) 103246447(GRK4)
RRO: 
104672234(GRK5) 104678955(GRK4) 104680460(GRK6)
RBB: 
108513853(GRK5) 108522739(GRK4) 108544772(GRK6)
CJC: 
SBQ: 
101030769(GRK6) 101037649(GRK5) 101054298(GRK4)
MMU: 
14772(Grk4) 14773(Grk5) 26385(Grk6)
RNO: 
59075(Grk5) 59076(Grk6) 59077(Grk4)
CGE: 
100767022(Grk4) 100771151(Grk5) 103161260(Grk6)
NGI: 
103729285(Grk5) 103732366(Grk6) 103741150(Grk4)
HGL: 
CCAN: 
OCU: 
TUP: 
102474598(GRK6) 102480420(GRK4) 102485965(GRK5)
CFA: 
100684653(GRK6) 479075(GRK4) 486915(GRK5)
AML: 
100466557(GRK4) 100478616(GRK6) 100480732(GRK5)
UMR: 
103657694(GRK5) 103664442(GRK6) 103676663(GRK4)
FCA: 
101086226(GRK4) 101087379(GRK6) 101089047(GRK5)
PTG: 
102955344(GRK4) 102962153(GRK5) 102968971(GRK6)
AJU: 
106969373(GRK5) 106975413(GRK6) 106978855(GRK4)
BTA: 
281801(GRK5) 512489(GRK4) 521413(GRK6)
BOM: 
102271649(GRK6) 102272970(GRK5) 102283303(GRK4)
BIU: 
109553055(GRK5) 109560743(GRK4) 109561904(GRK6)
PHD: 
102321739(GRK6) 102336686(GRK4) 102338691(GRK5)
CHX: 
102183500(GRK4) 102186301(GRK6) 102190578(GRK5)
OAS: 
SSC: 
100152937(GRK5) 100519668(GRK4) 110259389(GRK6)
CFR: 
CDK: 
105099593(GRK6) 105103924(GRK4) 105104188(GRK5)
BACU: 
103005786(GRK5) 103011898(GRK4) 103017883(GRK6)
LVE: 
ECB: 
100053624(GRK4) 100065919(GRK5) 100068570(GRK6)
EPZ: 
EAI: 
106825835(GRK4) 106827137(GRK6) 106836364(GRK5)
MYB: 
102246592(GRK5) 102255277(GRK6) 102260906(GRK4)
MYD: 
HAI: 
109382992(GRK5) 109389794(GRK6) 109390911(GRK4)
RSS: 
109434229(GRK6) 109434506(GRK4) 109444124(GRK5)
PALE: 
102877766(GRK5) 102881935(GRK6) 102893603(GRK4)
LAV: 
100663377(GRK5) 100663381(GRK6) 100670615(GRK4)
MDO: 
100021366(GRK4) 100026232(GRK5) 100031943(GRK6)
SHR: 
100915281(GRK5) 100921906(GRK6) 100931079(GRK4)
OAA: 
100074050(GRK4) 100084269(GRK5) 100084380(GRK6)
GGA: 
416361(GRK6) 422879(GRK4) 423929(GRK5)
MGP: 
CJO: 
107314005(GRK4) 107316182(GRK5) 107320438(GRK6)
APLA: 
ACYG: 
106034651(GRK4) 106042780(GRK6) 106045200(GRK5)
TGU: 
100227306(GRK5) 100229994(GRK6) 100232432(GRK4)
GFR: 
102035414(GRK5) 102036653(GRK4) 102041334(GRK6)
FAB: 
101807573(GRK4) 101814948(GRK5) 101818256(GRK6)
PHI: 
102106169(GRK5) 102110063(GRK4) 102110395(GRK6)
PMAJ: 
107202831(GRK4) 107206946(GRK5) 107210768(GRK6)
CCW: 
104689515(GRK6) 104690771(GRK4) 104694850(GRK5)
FPG: 
FCH: 
CLV: 
AAM: 
106489500(GRK5) 106489905(GRK6) 106498749(GRK4)
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
XTR: 
100379796(grk6) 100497344(grk5) 448587(grk4) 550070(grk5)
NPR: 
DRE: 
560761(grk4) 560806(grk5) 561288(grk6) 567452(grk5l)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103177327(grk6) 103186330(grk4) 103186576(grk5)
BFO: 
CIN: 
SPU: 
APLC: 
SKO: 
100374101(GRK5)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD21578(Dsim_GD21578)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
AME: 
410632(Gprk2)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
PXY: 
API: 
DNX: 
PHU: 
FCD: 
DPX: 
ISC: 
TUT: 
CEL: 
CBR: 
CBG01947(Cbr-grk-1)
NAI: 
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
AAF: 
 » show all
Taxonomy
Reference
1  [PMID:8288567]
  Authors
Kunapuli P, Onorato JJ, Hosey MM, Benovic JL.
  Title
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
  Journal
J. Biol. Chem. 269 (1994) 1099-105.
  Sequence
[hsa:2869]
Reference
2  [PMID:8120045]
  Authors
Premont RT, Koch WJ, Inglese J, Lefkowitz RJ.
  Title
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
  Journal
J. Biol. Chem. 269 (1994) 6832-41.
  Sequence
[bta:281801]
Reference
3  [PMID:14654303]
  Authors
Willets JM, Challiss RA, Nahorski SR.
  Title
Non-visual GRKs: are we seeing the whole picture?
  Journal
Trends. Pharmacol. Sci. 24 (2003) 626-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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