KEGG   ENZYME: 2.7.11.28Help
Entry
EC 2.7.11.28                Enzyme                                 

Name
tropomyosin kinase;
tropomyosin kinase (phosphorylating);
STK
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:tropomyosin O-phosphotransferase
Reaction(IUBMB)
ATP + tropomyosin = ADP + O-phosphotropomyosin [RN:R02980]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
tropomyosin [CPD:C00839]
Product
ADP [CPD:C00008];
O-phosphotropomyosin [CPD:C03016]
Comment
The enzyme phosphorylates casein equally well, and histone and phosvitin to a lesser extent. The acceptor is a serine residue in the protein.
History
EC 2.7.11.28 created 1990 as EC 2.7.1.132, transferred 2005 to EC 2.7.11.28
Reference
1  [PMID:3593768]
  Authors
deBelle I, Mak AS.
  Title
Isolation and characterization of tropomyosin kinase from chicken embryo.
  Journal
Biochim. Biophys. Acta. 925 (1987) 17-26.
  Organism
Gallus gallus
Reference
2  [PMID:6325440]
  Authors
Montgomery K, Mak AS.
  Title
In vitro phosphorylation of tropomyosin by a kinase from chicken embryo.
  Journal
J. Biol. Chem. 259 (1984) 5555-60.
  Organism
Gallus gallus
Reference
3  [PMID:3166994]
  Authors
Watson MH, Taneja AK, Hodges RS, Mak AS.
  Title
Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues.
  Journal
Biochemistry. 27 (1988) 4506-12.
  Organism
Gallus gallus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
90804-56-1

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