KEGG   ENZYME: 2.7.11.29Help
Entry
EC 2.7.11.29                Enzyme                                 

Name
low-density-lipoprotein receptor kinase;
ATP:low-density-lipoprotein-L-serine O-phosphotransferase;
LDL receptor kinase;
[low-density-lipoprotein] kinase;
low-density lipoprotein kinase;
low-density-lipoprotein receptor kinase (phosphorylating);
STK7
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase
Reaction(IUBMB)
ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
Reaction(KEGG)
(other) R04403
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Substrate
ATP [CPD:C00002];
[low-density-lipoprotein receptor]-L-serine
Product
ADP [CPD:C00008];
[low-density-lipoprotein receptor]-O-phospho-L-serine
Comment
Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
History
EC 2.7.11.29 created 1990 as EC 2.7.1.131, transferred 2005 to EC 2.7.11.29
Reference
1  [PMID:3100530]
  Authors
Kishimoto A, Brown MS, Slaughter CA, Goldstein JL.
  Title
Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II.
  Journal
J. Biol. Chem. 262 (1987) 1344-51.
Reference
2  [PMID:3597414]
  Authors
Kishimoto A, Goldstein JL, Brown MS.
  Title
Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein.
  Journal
J. Biol. Chem. 262 (1987) 9367-73.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
107445-00-1

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