KEGG   ENZYME: 2.7.11.6Help
Entry
EC 2.7.11.6                 Enzyme                                 

Name
[tyrosine 3-monooxygenase] kinase;
pheochromocytoma tyrosine hydroxylase-associated kinase;
STK4;
tyrosine 3-monooxygenase kinase (phosphorylating)
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[tyrosine-3-monoxygenase] phosphotransferase
Reaction(IUBMB)
ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]
Reaction(KEGG)
(other) R04275
Show
Substrate
ATP [CPD:C00002];
[tyrosine-3-monooxygenase]
Product
ADP [CPD:C00008];
phospho-[tyrosine-3-monooxygenase]
Comment
The enzyme has no activating compound but is specific for its substrate, with which it co-purifies. Requires Mg2+. Activates EC 1.14.16.2, tyrosine 3-monooxygenase, by phosphorylation.
History
EC 2.7.11.6 created 1989 as EC 2.7.1.124, transferred 2005 to EC 2.7.11.6
Reference
1  [PMID:2872947]
  Authors
Pigeon D, Drissi-Daoudi R, Gros F, Thibault J.
  Title
[Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase]
  Journal
C. R. Acad. Sci. III. 302 (1986) 435-8.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:2883182]
  Authors
Pigeon D, Ferrara P, Gros F, Thibault J.
  Title
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
  Journal
J. Biol. Chem. 262 (1987) 6155-8.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
103537-12-8

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