KEGG   ENZYME: 2.7.11.8Help
Entry
EC 2.7.11.8                 Enzyme                                 
Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
(other) R00162
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Substrate
ATP [CPD:C00002];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:C00008];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
Orthology
K08290  
Fas-activated serine/threonine kinase
Genes
HSA: 
10922(FASTK)
PTR: 
472626(FASTK)
PPS: 
100978359(FASTK)
GGO: 
101150125(FASTK)
PON: 
100171584(FASTK)
MCC: 
714020(FASTK)
MMU: 
66587(Fastk)
RNO: 
296741(Fastk)
CFA: 
482802(FASTK)
AML: 
100482824(FASTK)
FCA: 
101082140(FASTK)
BTA: 
509781(FASTK)
SSC: 
100233181(FASTK)
ECB: 
100063473(FASTK)
GGA: 
426636(FASTK)
MGP: 
100544059
DRE: 
564534(fastk)
 » show all
Taxonomy
Reference
1  [PMID:7544399]
  Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
  Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
  Journal
J. Exp. Med. 182 (1995) 865-74.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:15572676]
  Authors
Li W, Simarro M, Kedersha N, Anderson P.
  Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
  Journal
Mol. Cell. Biol. 24 (2004) 10718-32.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
170347-50-9
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