| Entry |
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| Name |
Goodpasture-antigen-binding protein kinase;
GPBPK;
GPBP kinase;
STK11;
Goodpasture antigen-binding protein kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
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| Sysname |
ATP:[Goodpasture antigen-binding protein] phosphotransferase
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| Reaction(IUBMB) |
ATP + [Goodpasture antigen-binding protein] = ADP + [Goodpasture antigen-binding phosphoprotein]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
[Goodpasture antigen-binding protein]
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| Product |
ADP [CPD: C00008];
[Goodpasture antigen-binding phosphoprotein]
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| Comment |
This serine/threonine kinase specifically binds to and phosphorylates the N-terminal region of the human Goodpasture antigen, which is located on the alpha3 chain of collagen IV and is involved in autoimmune disease.
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| Reference |
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| Authors |
Raya A, Revert F, Navarro S, Saus J. |
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| Title |
Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen. |
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| Journal |
J. Biol. Chem. 274 (1999) 12642-9. |
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| Organism |
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| Reference |
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| Authors |
Raya A, Revert-Ros F, Martinez-Martinez P, Navarro S, Rosello E, Vieites B, Granero F, Forteza J, Saus J. |
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| Title |
Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis. |
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| Journal |
J. Biol. Chem. 275 (2000) 40392-9. |
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| Organism |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 230316-19-5 |
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