KEGG   ENZYME: 2.7.13.1Help
Entry
EC 2.7.13.1                 Enzyme                                 

Name
protein-histidine pros-kinase;
ATP:protein-L-histidine N-pros-phosphotransferase;
histidine kinase (ambiguous);
histidine protein kinase (ambiguous);
protein histidine kinase (ambiguous);
protein kinase (histidine) (ambiguous);
HK2
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-histidine kinases
BRITE hierarchy
Sysname
ATP:protein-L-histidine Npi-phosphotransferase
Reaction(IUBMB)
ATP + protein L-histidine = ADP + protein Npi-phospho-L-histidine [RN:R02625]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein L-histidine [CPD:C00615]
Product
ADP [CPD:C00008];
protein Npi-phospho-L-histidine [CPD:C04261]
Comment
A number of histones can act as acceptor.
History
EC 2.7.13.1 created 1989 as EC 2.7.3.11, transferred 2005 to EC 2.7.13.1
Orthology
K05962  
protein-histidine pros-kinase
Genes
AZO: 
azo0458(ragB) azo0518(nifL) azo0568(vsrA) azo1492(divJ) azo1504(moxY) azo2575(gacS) azo2672 azo2746(envZ2) azo3616(envZ3) azo3810(hoxJ) azo3909(mnsA)
RBA: 
Taxonomy
Reference
1  [PMID:7196259]
  Authors
Fujitaki JM, Fung G, Oh EY, Smith RA.
  Title
Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance.
  Journal
Biochemistry. 20 (1981) 3658-64.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:4066704]
  Authors
Huebner VD, Matthews HR.
  Title
Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia.
  Journal
J. Biol. Chem. 260 (1985) 16106-13.
  Organism
Physarum polycephalum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99283-67-7

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