KEGG   ENZYME: 2.7.2.15Help
Entry
EC 2.7.2.15                 Enzyme                                 

Name
propionate kinase;
PduW;
TdcD;
propionate/acetate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
BRITE hierarchy
Sysname
ATP:propanoate phosphotransferase
Reaction(IUBMB)
ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
propanoate [CPD:C00163]
Product
ADP [CPD:C00008];
propanoyl phosphate [CPD:C02876]
Comment
Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].
History
EC 2.7.2.15 created 2005
Pathway
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K00932  propionate kinase
K19697  propionate kinase
Genes
ECO: b3115(tdcD)
ECJ: JW5806(tdcD)
ECD: ECDH10B_3289(tdcD)
EBW: BWG_2823(tdcD)
ECOK: ECMDS42_2583(tdcD)
ECE: Z4467(tdcD)
ECS: ECs3995
ECF: ECH74115_4428(tdcD)
ETW: ECSP_4087(tdcD)
ELX: CDCO157_3736
EOJ: ECO26_4220(tdcD)
EOI: ECO111_3939(tdcD)
EOH: ECO103_3862(tdcD)
ECG: E2348C_3405(tdcD)
EOK: G2583_3837(tdcD)
ECC: c3873 c4530(tdcD)
ECP: ECP_3208
ECI: UTI89_C3550(tdcD)
ECX: EcHS_A3303(tdcD)
ECW: EcE24377A_3589(tdcD)
ECM: EcSMS35_3411(tdcD)
ECY: ECSE_3399
ECR: ECIAI1_3264(tdcD)
ECK: EC55989_3532(tdcD)
ECT: ECIAI39_3616(tdcD)
EOC: CE10_3647(tdcD)
EUM: ECUMN_3599(tdcD)
ELO: EC042_3407(tdcD)
ELH: ETEC_3383
ESE: ECSF_2955
ESO: O3O_22280
ESM: O3M_03405
ESL: O3K_03365
EBR: ECB_02982(tdcD)
EBD: ECBD_0625
EKF: KO11_07110(tdcD)
EAB: ECABU_c35320(tdcD)
EDJ: ECDH1ME8569_3008(tdcD)
EIH: ECOK1_3542(tdcD)
ENA: ECNA114_4344(tdcD)
EUN: UMNK88_3870(ackA)
ELW: ECW_m3384(tdcD)
ELL: WFL_16540(tdcD)
ELC: i14_3561(tdcD)
ELD: i02_3561(tdcD)
ELP: P12B_c3231(tdcD)
EBL: ECD_02982(tdcD)
EBE: B21_02933(tdcD)
ELF: LF82_2233(tdcD)
ECOI: ECOPMV1_03429(tdcD)
ECOJ: P423_17570
ECOO: ECRM13514_4076(tdcD)
ECOH: ECRM13516_3879(tdcD)
ECOS: EC958_3518(tdcD)
EFE: EFER_2027
EAL: EAKF1_ch2818(tdcD)
STY: STY2262 STY3424(tdcD)
STT: t0817 t3162(tdcD)
STM: STM2057(pduW) STM3242(tdcD)
SEO: STM14_2546(pduW) STM14_3924(tdcD)
SEY: SL1344_2033(pduW) SL1344_3214(tdcD)
SEJ: STMUK_2087(pduW) STMUK_3231(tdcD)
SEB: STM474_2142(pduW) STM474_3396(tdcD)
SEF: UMN798_2223(pduW) UMN798_3526(tdcD)
SENR: STMDT2_20301(pduW) STMDT2_31341(tdcD)
SEND: DT104_21141(pduW) DT104_32371(tdcD)
SPT: SPA0814(pduW) SPA3111(tdcD)
SEI: SPC_1657(pduW) SPC_3318(tdcD)
SEC: SCH_2066(pduW) SCH_3188(tdcD)
SEH: SeHA_C2280(ackA) SeHA_C3537(ackA)
SEE: SNSL254_A2234(ackA) SNSL254_A3504(ackA)
SEW: SeSA_A2227(ackA) SeSA_A3433(ackA)
SEA: SeAg_B2180(ackA) SeAg_B3430(ackA)
SED: SeD_A2393(ackA) SeD_A3600(ackA)
SEG: SG2086(pduW) SG3139(tdcD)
SEL: SPUL_0843(pduW) SPUL_3255(tdcD)
SEGA: SPUCDC_0843(pduW) SPUCDC_3241(tdcD)
SET: SEN2055(pduW) SEN3083(tdcD)
SBG: SBG_2879(tdcD)
SBZ: A464_3326
SFL: SF3155(tdcD)
SFX: S3367(tdcD)
SFV: SFV_3156(tdcD)
SFE: SFxv_3462(tdcD)
SFN: SFy_4506
SFS: SFyv_4580
SFT: NCTC1_03420(tdcD)
SSN: SSON_3272(tdcD)
SBO: SBO_2980(tdcD)
SBC: SbBS512_E3242(tdcD)
SDY: SDY_3307(tdcD)
ENC: ECL_04509
ECLO: ENC_33660
EEC: EcWSU1_03927(tdcD)
ECLX: LI66_19690
ECLY: LI62_21665
ECLZ: LI64_18805
KPN: KPN_02293(tdcD) KPN_03222(pduW)
KPU: KP1_3409(tdcD) KP1_4491(pduW)
KPT: VK055_0163(ackA) VK055_4303(ackA2)
KPE: KPK_0893(pduW) KPK_2016(tdcD)
KPR: KPR_1811(pduW) KPR_3203(tdcD)
KPX: PMK1_00703(pduW) PMK1_04654(tdcD)
KPNK: BN49_0886(pduW) BN49_3394(tdcD)
KOX: KOX_01540
KOE: A225_4773
EAE: EAE_22040
EAR: CCG29523
CRO: ROD_21431(pduW) ROD_47621(tdcD)
EBF: D782_0577
YEN: YE0338(tdcD) YE2747(pduW)
YEW: CH47_2096(ackA) CH47_3136(ackA)
YET: CH48_1252(ackA) CH48_3134(ackA)
YEE: YE5303_31801(pduW)
YAL: AT01_2860(ackA) AT01_4016(ackA)
YFR: AW19_702(ackA)
YIN: CH53_1391(ackA) CH53_3350(ackA)
YKR: CH54_960(ackA)
YRU: BD65_1333(ackA)
PEC: W5S_4257
SOD: Sant_2126(tdcD)
ETR: ETAE_0896(tdcD)
ETD: ETAF_0836
ETE: ETEE_2779(tdcD)
AVR: B565_1141
TAU: Tola_1703
FJG: BB050_04356(pduW)
 » show all
Taxonomy
Reference
1  [PMID:9484901]
  Authors
Hesslinger C, Fairhurst SA, Sawers G.
  Title
Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.
  Journal
Mol. Microbiol. 27 (1998) 477-92.
  Sequence
[eco:b3115]
Reference
2  [PMID:12700259]
  Authors
Palacios S, Starai VJ, Escalante-Semerena JC.
  Title
Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.
  Journal
J. Bacteriol. 185 (2003) 2802-10.
Reference
3  [PMID:10498722]
  Authors
Wei Y, Miller CG.
  Title
Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium.
  Journal
J. Bacteriol. 181 (1999) 6092-7.
  Sequence
[stm:STM3242]
Reference
4  [PMID:15774882]
  Authors
Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG.
  Title
Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase.
  Journal
J. Bacteriol. 187 (2005) 2386-94.
Reference
5  [PMID:16508089]
  Authors
Simanshu DK, Murthy MR.
  Title
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 61 (2005) 52-5.
Reference
6  [PMID:16139298]
  Authors
Simanshu DK, Savithri HS, Murthy MR.
  Title
Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
  Journal
J. Mol. Biol. 352 (2005) 876-92.
  Sequence
[stm:STM3242]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.15
IUBMB Enzyme Nomenclature: 2.7.2.15
ExPASy - ENZYME nomenclature database: 2.7.2.15
BRENDA, the Enzyme Database: 2.7.2.15
CAS: 39369-28-3

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