KEGG   ENZYME: 2.7.2.15Help
Entry
EC 2.7.2.15                 Enzyme                                 

Name
propionate kinase;
PduW;
TdcD;
propionate/acetate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
BRITE hierarchy
Sysname
ATP:propanoate phosphotransferase
Reaction(IUBMB)
ATP + propanoate = ADP + propanoyl phosphate [RN:R01353]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
propanoate [CPD:C00163]
Product
ADP [CPD:C00008];
propanoyl phosphate [CPD:C02876]
Comment
Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria [1]. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate [1].
History
EC 2.7.2.15 created 2005
Pathway
Propanoate metabolism
Orthology
K00932  
propionate kinase
Genes
ECO: 
b3115(tdcD)
ECJ: 
Y75_p3039(tdcD)
ECD: 
EBW: 
BWG_2823(tdcD)
ECOK: 
ECE: 
Z4467(tdcD)
ECS: 
ECF: 
ETW: 
ECSP_4087(tdcD)
ELX: 
EOJ: 
EOI: 
EOH: 
ECG: 
EOK: 
ELR: 
ECC: 
c4530(tdcD)
ECP: 
ECI: 
ECV: 
ECX: 
ECW: 
ECM: 
ECY: 
ECR: 
ECQ: 
ECK: 
ECT: 
EOC: 
CE10_3647(tdcD)
EUM: 
ECZ: 
ELO: 
ELN: 
ELH: 
ESE: 
ESO: 
ESM: 
ESL: 
ECL: 
EBR: 
ECB_02982(tdcD)
EBD: 
EKO: 
EKF: 
EAB: 
EDH: 
EDJ: 
EIH: 
ENA: 
ELU: 
EUN: 
ELW: 
ECW_m3384(tdcD)
ELL: 
WFL_16540(tdcD)
ELC: 
i14_3561(tdcD)
ELD: 
i02_3561(tdcD)
ELP: 
EBL: 
ECD_02982(tdcD)
EBE: 
B21_02933(tdcD)
ELF: 
LF82_2233(tdcD)
ECOA: 
ECOL: 
ECOI: 
ECOJ: 
ECOO: 
STY: 
STY3424(tdcD)
STT: 
t3162(tdcD)
SEX: 
SENT: 
STM: 
STM2057(pduW) STM3242(tdcD)
SEO: 
SEV: 
SEY: 
SEM: 
SEJ: 
SEB: 
SEF: 
SETU: 
SETC: 
SEEN: 
SENR: 
SEND: 
SPT: 
SPA0814(pduW) SPA3111(tdcD)
SEK: 
SPQ: 
SEI: 
SPC_3318(tdcD)
SEC: 
SC2066(pduW) SC3188(tdcD)
SEH: 
SHB: 
SENH: 
SEEH: 
SEE: 
SENN: 
SEW: 
SEA: 
SENS: 
SED: 
SeD_A3600(ackA)
SEG: 
SG3139(tdcD)
SEL: 
SPUL_3255(tdcD)
SEGA: 
SET: 
SEN3083(tdcD)
SENJ: 
SEEC: 
SEEB: 
SEEP: 
SENB: 
BN855_33230(SBOV33111)
SENE: 
SES: 
SBG: 
SBG_2879(tdcD)
SBZ: 
YEN: 
YE0338(tdcD) YE2747(pduW)
YEP: 
YEY: 
SFL: 
SF3155(tdcD)
SFX: 
S3367(tdcD)
SFV: 
SFV_3156(tdcD)
SFE: 
SFxv_3462(tdcD)
SSN: 
SSON_3272(tdcD)
SSJ: 
SBO: 
SBO_2980(tdcD)
SBC: 
SDY: 
SDY_3307(tdcD)
SDZ: 
PEC: 
SOD: 
Sant_2126(tdcD)
ENT: 
ENC: 
ENO: 
ECLO: 
EEC: 
ENL: 
ESC: 
EAS: 
EAU: 
EAE: 
EAR: 
KPN: 
KPN_02293(tdcD)
KPU: 
KP1_3409(tdcD)
KPM: 
KPP: 
KPE: 
KPK_2016(tdcD)
KPO: 
KPR: 
KPR_3203(tdcD)
KPJ: 
KPI: 
KVA: 
CKO: 
CRO: 
ROD_47621(tdcD)
CFD: 
ETR: 
ETAE_0896(tdcD)
ETD: 
ETC: 
ROR: 
EBF: 
VEJ: 
AVR: 
 » show all
Taxonomy
Reference
1  [PMID:9484901]
  Authors
Hesslinger C, Fairhurst SA, Sawers G.
  Title
Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate.
  Journal
Mol. Microbiol. 27 (1998) 477-92.
  Organism
Escherichia coli
  Sequence
[eco:b3115]
Reference
2  [PMID:12700259]
  Authors
Palacios S, Starai VJ, Escalante-Semerena JC.
  Title
Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.
  Journal
J. Bacteriol. 185 (2003) 2802-10.
  Organism
Salmonella enterica
Reference
3  [PMID:10498722]
  Authors
Wei Y, Miller CG.
  Title
Characterization of a group of anaerobically induced, fnr-dependent genes of Salmonella typhimurium.
  Journal
J. Bacteriol. 181 (1999) 6092-7.
  Organism
Salmonella typhimurium
  Sequence
[stm:STM3242]
Reference
4  [PMID:15774882]
  Authors
Ingram-Smith C, Gorrell A, Lawrence SH, Iyer P, Smith K, Ferry JG.
  Title
Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase.
  Journal
J. Bacteriol. 187 (2005) 2386-94.
  Organism
Methanosarcina thermophila
Reference
5  [PMID:16508089]
  Authors
Simanshu DK, Murthy MR.
  Title
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of propionate kinase (TdcD) from Salmonella typhimurium.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 61 (2005) 52-5.
  Organism
Salmonella typhimurium
Reference
6  [PMID:16139298]
  Authors
Simanshu DK, Savithri HS, Murthy MR.
  Title
Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
  Journal
J. Mol. Biol. 352 (2005) 876-92.
  Organism
Salmonella typhimurium
  Sequence
[stm:STM3242]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39369-28-3

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