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Entry
EC 2.7.4.21                 Enzyme                                 
Name
inositol-hexakisphosphate kinase;
ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase
Reaction(IUBMB)
(1) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [RN:R09087];
(2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)
Reaction(KEGG)
R09087;
(other) R05799
Show
Substrate
ATP [CPD:C00002];
1D-myo-inositol hexakisphosphate [CPD:C01204];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:C01284]
Product
ADP [CPD:C00008];
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate [CPD:C11526];
1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown)
Comment
Three mammalian isoforms are known to exist.
Orthology
K07756  
inositol-hexakisphosphate kinase
K13024  
inositol hexakisphosphate/diphosphoinositol-pentakisphosphate kinase
Genes
HSA: 
117283(IP6K3) 23262(PPIP5K2) 51447(IP6K2) 9677(PPIP5K1) 9807(IP6K1)
PTR: 
100608132 453381(PPIP5K1) 460379(IP6K1) 461976(PPIP5K2) 471985(IP6K3)
PPS: 
100969708(PPIP5K2) 100976000(IP6K2) 100981471(IP6K3) 100986441(IP6K1)
GGO: 
101125695(IP6K3) 101142717(IP6K1) 101151797(PPIP5K2) 101152480(IP6K2) 101153329(PPIP5K1)
PON: 
100171621(PPIP5K2) 100171866(IP6K1) 100172292(IP6K3) 100450315(IP6K2)
MCC: 
703458(PPIP5K2) 705576(IP6K1) 710588 718209(IP6K3)
MMU: 
227399(Ppip5k2) 271424(Ip6k3) 27399(Ip6k1) 327655(Ppip5k1) 76500(Ip6k2)
RNO: 
311355(Ppip5k1) 50560(Ip6k1) 59268(Ip6k2) 688862(Ip6k3)
CFA: 
478276(PPIP5K1) 481747(IP6K3) 484765(IP6K1) 488883(PPIP5K2) 612831(IP6K2)
AML: 
FCA: 
101086884(IP6K1) 101089992(IP6K2) 101091503(PPIP5K2) 101093936(IP6K3) 101098233(PPIP5K1)
BTA: 
508236(IP6K2) 510684(PPIP5K1) 521960(IP6K3) 534029(IP6K1) 780855(PPIP5K2)
SSC: 
100152613 100513565(IP6K1) 100520287 100523922(IP6K2) 100625306(PPIP5K2)
ECB: 
100052910(IP6K1) 100053066(IP6K3) 100053738(IP6K2) 100064726(PPIP5K2)
MDO: 
100011533(PPIP5K1) 100020552 100021353 100027589 100030703(PPIP5K2)
SHR: 
100918551(IP6K3) 100919487(IP6K2) 100923495(IP6K1) 100925666(PPIP5K2) 100927893(PPIP5K1)
OAA: 
100073453(IP6K2) 100074142(PPIP5K2) 100088751 100089590
GGA: 
100857294(IP6K1) 415587(PPIP5K1) 416010(IP6K2) 419908(IP6K3) 427276(PPIP5K2)
MGP: 
100544318 100546263(IP6K1) 100548969(IP6K2)
TGU: 
100224061(PPIP5K2) 100225111(PPIP5K1) 100225979(IP6K1) 100227893(IP6K2) 100230361(MNF1)
ACS: 
100554395(ppip5k1) 100558855 100564056 100566479 100568184
XLA: 
443957(ip6k1) 444642(ip6k2-a) 495012(ppip5k2)
XTR: 
100135086(ppip5k2) 100493265(ppip5k1) 548709(ip6k2) 780040(ip6k1)
DRE: 
322041(ip6k2) 436662 449862(ppip5k2) 556748(ppip5k1) 564478(ip6k1)
TRU: 
101061909 101078927 101080152
OLA: 
101155919 101159326 101165380
BFO: 
BRAFLDRAFT_118894 BRAFLDRAFT_123507
CIN: 
100182374 100182708(ppip5k1)
SPU: 
574572(PPIP5K2) 585505
DME: 
Dmel_CG14616(l(1)G0196)
DPO: 
Dpse_GA13115
DER: 
Dere_GG19746
DPE: 
Dper_GL13299
DSE: 
Dsec_GM11733
DSI: 
Dsim_GD24413
DWI: 
Dwil_GK25772
DYA: 
Dyak_GE17941
DGR: 
Dgri_GH24076
DMO: 
Dmoj_GI14473
DVI: 
Dvir_GJ18811
AGA: 
AgaP_AGAP000926
AAG: 
AaeL_AAEL008950
CQU: 
CpipJ_CPIJ012460
AME: 
725179
NVI: 
100115546(NV15853)
TCA: 
663934
API: 
100158865
PHU: 
Phum_PHUM041400 Phum_PHUM208020
ISC: 
IscW_ISCW008668
CEL: 
CELE_F46F11.1(F46F11.1)
CBR: 
CBG14896 CBG24497
BMY: 
Bm1_41900 Bm1_57300
TSP: 
Tsp_08677 Tsp_10123
SMM: 
Smp_045860.1
NVE: 
NEMVE_v1g20017 NEMVE_v1g243051
HMG: 
100197158 100198226 100202454
TAD: 
TRIADDRAFT_19973 TRIADDRAFT_55020
AQU: 
100635064 100640906
ALY: 
ARALYDRAFT_488348
GMX: 
100776866
MTR: 
MTR_7g009060
CSV: 
101210866
RCU: 
RCOM_0854040
POP: 
POPTR_831208
VVI: 
100262888
DOSA: 
Os03t0689100-01(Os03g0689100)
BDI: 
100830891
SBI: 
SORBI_01g011620(SORBIDRAFT_01g011620)
SMO: 
SELMODRAFT_429797 SELMODRAFT_444048
PPP: 
PHYPADRAFT_184130 PHYPADRAFT_187835
CRE: 
CHLREDRAFT_115639(FAP160)
VCN: 
VOLCADRAFT_56293
OTA: 
Ot03g03030
MBR: 
MONBRDRAFT_37460
EHI: 
EHI_051050(98.t00022)
EDI: 
EDI_233900
PBE: 
PB000565.02.0
PTM: 
GSPATT00006245001 GSPATT00009575001
PTI: 
PHATR_46684
TPS: 
THAPSDRAFT_12441
PIF: 
PITG_03590 PITG_17745
 » show all
Taxonomy
Reference
1  [PMID:10574768]
  Authors
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH.
  Title
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
  Journal
Curr. Biol. 9 (1999) 1323-6.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
2  [PMID:10567691]
  Authors
Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF.
  Title
PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase.
  Journal
FEBS. Lett. 461 (1999) 169-72.
  Organism
Xenopus sp.
Reference
3  [PMID:9359429]
  Authors
Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Brocker M, Shears SB, Mayr GW.
  Title
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells.
  Journal
Biochem. J. 327 ( Pt 2) (1997) 553-60.
  Organism
Homo sapiens [GN:hsa], Cricetulus griseus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
176898-37-6
DBGET integrated database retrieval system