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Entry
EC 2.7.4.26                 Enzyme                                 

Name
isopentenyl phosphate kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:isopentenyl phosphate phosphotransferase
Reaction(IUBMB)
ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate [RN:R10093]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
isopentenyl phosphate [CPD:C20345]
Product
ADP [CPD:C00008];
isopentenyl diphosphate [CPD:C00129]
Comment
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as dimethylallyl phosphate, geranyl phosphate, or fosfomycin.
History
EC 2.7.4.26 created 2012
Pathway
Terpenoid backbone biosynthesis
Orthology
K06981  
isopentenyl phosphate kinase
Genes
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
HAU: 
ATM: 
CAP: 
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MAC: 
MBA: 
MMA: 
MBU: 
MMH: 
MEV: 
MZH: 
MPY: 
MHZ: 
MTP: 
MCJ: 
MHI: 
MHU: 
MLA: 
MEM: 
MBG: 
MPI: 
MBN: 
MFO: 
MPL: 
MPD: 
MEZ: 
RCI: 
MER: 
MTH: 
MMG: 
MST: 
MSI: 
MRU: 
MEB: 
MEL: 
MEW: 
METH: 
MFV: 
MKA: 
MAX: 
AFU: 
APO: 
AVE: 
AST: 
FPL: 
HAL: 
VNG1148G(argB)
HSL: 
HMA: 
rrnAC0078(argB1)
HHI: 
HAH_0835(argB1)
HHN: 
HWA: 
HWC: 
NPH: 
NMO: 
HLA: 
HUT: 
HTI: 
HMU: 
HTU: 
NMG: 
HVO: 
HME: 
HJE: 
HBO: 
HXA: 
NAT: 
NPE: 
NGE: 
HRU: 
NOU: 
SALI: 
TAC: 
TVO: 
PTO: 
FAC: 
TAR: 
PHO: 
PAB: 
PAB0373(argB-like)
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_1729(fomA)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
ABI: 
ACF: 
APE: 
ACJ: 
SMR: 
SHC: 
IHO: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
SSO: 
SOL: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
TPE: 
THB: 
ASC: 
CLG: 
FFO: 
NMR: 
NIR: 
NKR: 
CSY: 
NGA: 
CSU: 
KCR: 
HAH: 
 » show all
Taxonomy
Reference
1  [PMID:16621811]
  Authors
Grochowski LL, Xu H, White RH
  Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
  Journal
J. Bacteriol. 188 (2006) 3192-8.
  Organism
Methanocaldococcus jannaschii
  Sequence
[mja:MJ_0044]
Reference
2  [PMID:10570138]
  Authors
Lange BM, Croteau R
  Title
Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 13714-9.
  Organism
Mentha x piperita, Escherichia coli
Reference
3  [PMID:19928876]
  Authors
Chen M, Poulter CD
  Title
Characterization of thermophilic archaeal isopentenyl phosphate kinases.
  Journal
Biochemistry. 49 (2010) 207-17.
  Organism
Methanothermobacter thermautotrophicus, Thermoplasma acidophilum
  Sequence
[mth:MTH47] [tac:Ta0103]
Reference
4  [PMID:20402538]
  Authors
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD
  Title
X-ray structures of isopentenyl phosphate kinase.
  Journal
ACS. Chem. Biol. 5 (2010) 517-27.
  Organism
Methanothermobacter thermautotrophicus, Thermoplasma acidophilum
  Sequence
[mth:MTH47] [tac:Ta0103]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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