KEGG   ENZYME: 2.7.4.30Help
Entry
EC 2.7.4.30                 Enzyme                                 

Name
lipid A phosphoethanolamine transferase;
lipid A PEA transferase;
PmrA;
LptA
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
diacylphosphatidylethanolamine:lipid-A phosphoethanolaminetransferase
Reaction(IUBMB)
(1) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate);
(2) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate);
(3) diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
Substrate
diacylphosphatidylethanolamine;
lipid A;
lipid A 1-(2-aminoethyl diphosphate)
Product
diacylglycerol [CPD:C00165];
lipid A 1-(2-aminoethyl diphosphate);
lipid A 4'-(2-aminoethyl diphosphate);
lipid A 1,4'-bis(2-aminoethyl diphosphate)
Comment
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
History
EC 2.7.4.30 created 2015
Reference
1  [PMID:15489235]
  Authors
Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS
  Title
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A.
  Journal
J. Biol. Chem. 279 (2004) 55780-91.
Reference
2  [PMID:20384697]
  Authors
Herrera CM, Hankins JV, Trent MS
  Title
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
  Journal
Mol. Microbiol. 76 (2010) 1444-60.
Reference
3  [PMID:20194750]
  Authors
Cullen TW, Trent MS
  Title
A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 107 (2010) 5160-5.
Reference
4  [PMID:23192031]
  Authors
Anandan A, Piek S, Kahler CM, Vrielink A
  Title
Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 68 (2012) 1494-7.
Reference
5  [PMID:23810904]
  Authors
Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A
  Title
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin.
  Journal
J. Mol. Biol. 425 (2013) 3389-402.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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