KEGG   ENZYME: 2.7.7.31Help
Entry
EC 2.7.7.31                 Enzyme                                 

Name
DNA nucleotidylexotransferase;
terminal deoxyribonucleotidyltransferase;
terminal addition enzyme;
addase;
deoxynucleotidyl terminal transferase;
deoxyribonucleic acid nucleotidyltransferase;
deoxyribonucleic nucleotidyltransferase;
terminal deoxynucleotide transferase;
TdT
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidylexotransferase
Reaction(IUBMB)
2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Reaction(KEGG)
Substrate
2'-deoxyribonucleoside 5'-triphosphate [CPD:C00677];
DNAn [CPD:C00039]
Product
diphosphate [CPD:C00013];
DNAn+1 [CPD:C00039]
Comment
Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-.
History
EC 2.7.7.31 created 1972
Orthology
K00977  DNA nucleotidylexotransferase
Genes
HSA: 1791(DNTT)
PTR: 466167(DNTT)
PPS: 100976638(DNTT)
GGO: 101139353(DNTT)
PON: 100457001(DNTT)
NLE: 100579985(DNTT)
MCC: 704482(DNTT)
MCF: 102140598(DNTT)
CSAB: 103216324(DNTT)
RRO: 104682828(DNTT)
RBB: 108534467(DNTT)
CJC: 100397804(DNTT)
SBQ: 101034366(DNTT)
MMU: 21673(Dntt)
RNO: 294051(Dntt)
CGE: 100755735(Dntt)
NGI: 103733214(Dntt)
HGL: 101718847(Dntt)
CCAN: 109693658(Dntt)
OCU: 100353958(DNTT)
TUP: 102478219(DNTT)
CFA: 486815(DNTT)
AML: 100481079(DNTT)
UMR: 103672419(DNTT)
ORO: 101367975(DNTT)
FCA: 101097099(DNTT)
PTG: 102950975(DNTT)
AJU: 106984796(DNTT)
BTA: 281120(DNTT)
BOM: 102272669(DNTT)
BIU: 109579068(DNTT)
PHD: 102318656(DNTT)
CHX: 102168322(DNTT)
OAS: 101111504(DNTT)
SSC: 100518694(DNTT)
CFR: 102504796(DNTT)
CDK: 105084270(DNTT)
BACU: 103011471(DNTT)
LVE: 103081504(DNTT)
OOR: 101287627(DNTT)
ECB: 100061113(DNTT)
EPZ: 103552065(DNTT)
EAI: 106842101(DNTT)
MYB: 102253082(DNTT)
MYD: 102751385(DNTT)
HAI: 109380941(DNTT)
RSS: 109443887(DNTT)
PALE: 102888799(DNTT)
LAV: 100673573(DNTT)
TMU: 101349757
MDO: 554183(DNTT)
SHR: 100932555(DNTT)
OAA: 100074260(DNTT)
GGA: 396351(DNTT)
MGP: 100541055(DNTT)
CJO: 107316113(DNTT)
APLA: 101802023(DNTT) 101804368
ACYG: 106039193(DNTT)
TGU: 100220809(DNTT)
GFR: 102044003(DNTT)
FAB: 101816703(DNTT)
PHI: 102109349(DNTT)
PMAJ: 107206803(DNTT)
CCW: 104696134(DNTT)
FPG: 101919206(DNTT)
FCH: 102054379(DNTT)
CLV: 102094484(DNTT)
EGZ: 104129169(DNTT)
AAM: 106494703(DNTT)
ASN: 102384458(DNTT)
AMJ: 102561518(DNTT)
PSS: 102450678(DNTT)
CMY: 102947062(DNTT)
CPIC: 101934430(DNTT) 101942143
ACS: 100561065(dntt)
PVT: 110079723(DNTT)
PBI: 103057405(DNTT)
GJA: 107110244(DNTT)
XLA: 378525(dntt.L)
XTR: 100495475(dntt)
NPR: 108788987(DNTT)
DRE: 544653(dntt)
SRX: 107750146
SGH: 107562388 107565064(dntt)
IPU: 108262831(dntt)
AMEX: 103039195(dntt)
TRU: 445927(dntt)
LCO: 104921904(dntt)
NCC: 104950379
MZE: 101468990(dntt)
OLA: 101161827(dntt)
XMA: 102220485(dntt)
PRET: 103477089(dntt)
CSEM: 103387478(dntt)
LCF: 108886302(dntt)
HCQ: 109523082(dntt)
BPEC: 110166297
ELS: 105025934(dntt)
SFM: 108925807(dntt)
LCM: 102353127(DNTT)
CMK: 103180497(dntt)
SPU: 591373
SKO: 100373551
 » show all
Taxonomy
Reference
1  [PMID:5543689]
  Authors
Chang LM, Bollum FJ.
  Title
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.
  Journal
J. Biol. Chem. 246 (1971) 909-16.
Reference
2  [PMID:4288534]
  Authors
Gottesman ME, Canellakis ES.
  Title
The terminal nucleotidyltransferases of calf thymus nuclei.
  Journal
J. Biol. Chem. 241 (1966) 4339-52.
Reference
3  [PMID:14459258]
  Authors
KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES.
  Title
Studies on the incorporation of deoxyribonucleic acid.
  Journal
Biochim. Biophys. Acta. 55 (1962) 639-50.
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.31
IUBMB Enzyme Nomenclature: 2.7.7.31
ExPASy - ENZYME nomenclature database: 2.7.7.31
BRENDA, the Enzyme Database: 2.7.7.31
CAS: 9027-67-2

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