KEGG   ENZYME: 2.7.7.39Help
Entry
EC 2.7.7.39                 Enzyme                                 

Name
glycerol-3-phosphate cytidylyltransferase;
CDP-glycerol pyrophosphorylase;
cytidine diphosphoglycerol pyrophosphorylase;
cytidine diphosphate glycerol pyrophosphorylase;
CTP:glycerol 3-phosphate cytidylyltransferase;
Gro-PCT;
tagD (gene name);
tarD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:sn-glycerol-3-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol [RN:R00856]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
sn-glycerol 3-phosphate [CPD:C00093]
Product
diphosphate [CPD:C00013];
CDP-glycerol [CPD:C00513]
Comment
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.
History
EC 2.7.7.39 created 1972
Pathway
Glycerophospholipid metabolism
Orthology
K00980  
glycerol-3-phosphate cytidylyltransferase
Genes
ECC: 
ECQ: 
CTU: 
CTU_27380(tagD)
CRO: 
ROD_02971(tagD)
HDE: 
MSU: 
MS0658(tagD)
ASU: 
PSU: 
PPR: 
PBPRA2685(MW0603) PBPRA2703(TAGD1)
SFR: 
SBL: 
SLO: 
SSE: 
SPL: 
SHN: 
SHL: 
SWD: 
SWP: 
PAT: 
GAG: 
FBL: 
MAH: 
FPH: 
TCY: 
RMA: 
REU: 
BUR: 
NIS: 
NAM: 
NAMH_1603(tagD)
DPR: 
JAN: 
PDE: 
BSU: 
BSU35740(tagD)
BSR: 
I33_3703(tagD)
BSH: 
BSY: 
BSS: 
BST: 
GYO_3929(tarD)
BSO: 
BSN: 
BSQ: 
BSX: 
C663_3465(tarD)
BLI: 
BL02464(tagD)
BLD: 
BLi03818(tagD)
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAO: 
BAMF_3413(tagD)
BAZ: 
BQL: 
LL3_03708(tagD)
BXH: 
BQY: 
MUS_3915(tagD)
BAMI: 
BAE: 
BCL: 
ABC3101(tagD)
BPU: 
BPUM_3230(tagD)
BCK: 
BAG: 
BJS: 
OIH: 
OB2908(tagD)
GTN: 
AXL: 
AXY_20280(tagD)
SAU: 
SA0597(tagD)
SAV: 
SAV0641(tagD)
SAW: 
SAHV_0638(tagD)
SAH: 
SAJ: 
SAM: 
MW0603(tagD)
SAS: 
SAR: 
SAR0651(tagD)
SAC: 
SACOL0698(tagD)
SAX: 
SAA: 
SAO: 
SAE: 
NWMN_0611(tagD)
SAD: 
SAAV_0604(tagD)
SUU: 
SUV: 
SUE: 
SAOV_0676(tagD)
SUJ: 
SUK: 
SUC: 
ECTR2_593(tagD)
SUT: 
SUQ: 
SUZ: 
MS7_0692(tagD)
SUD: 
SUX: 
SUW: 
SUG: 
SAPIG0720(tagD)
SUF: 
SAB: 
SAB0591(tagD)
SUY: 
SAUB: 
C248_0723(tagD)
SAUM: 
SUH: 
SEP: 
SER: 
SERP0300(tagD)
SHA: 
SH2255(tagD)
SSP: 
SCA: 
SCA_0290(tagD)
SLG: 
SLN: 
SSD: 
SDT: 
SPSE_2109(tagD)
SWA: 
MCL: 
MCCL_0651(tagD)
LMO: 
lmo1089(tagD)
LMF: 
LMH: 
LMC: 
LMN: 
LMY: 
LMT: 
LMG: 
LMS: 
LMJ: 
LMQ: 
LMM7_1115(tagD)
LML: 
LMP: 
LMW: 
LMX: 
LMZ: 
LMON: 
LMOC: 
LMOS: 
LMOO: 
LMOY: 
LMOT: 
LMOA: 
LMOL: 
LMOG: 
LMOE: 
LMOB: 
LIN: 
LWE: 
lwe1066(tagD)
LSG: 
lse_0979(tagD)
LIV: 
LIV_1032(tagD)
ESI: 
EAN: 
Eab7_0567(tagD)
LLA: 
L150584(tagD2) L19816(tagD1)
LLK: 
LLKF_0212(tagD) LLKF_0953(tagD)
LLM: 
llmg_1606(tagD2)
LPL: 
lp_0267(tagD1) lp_1248(tagD2)
LPJ: 
JDM1_1056(tagD2)
LPT: 
zj316_1214(tagD2)
LPS: 
LPST_C0955(tagD2)
LJO: 
LJF: 
LAC: 
LBA0518(tagD)
LSA: 
LCA_1574(tagD)
LDB: 
Ldb1937(tagD)
LBU: 
LBR: 
LGA: 
LHE: 
LCR: 
LBH: 
LBN: 
LKE: 
WANG_1150(tagD)
PPE: 
EFA: 
EF1175(gct)
THL: 
TEH_15990(tagD)
LCI: 
LCK_01137(tagD1) LCK_01202(tagD2)
LKI: 
LEC: 
LGS: 
CPE: 
CLS: 
CXIVA_01280(TagD_(BS))
CPY: 
ERH: 
ERH_1439(tagD)
CAR: 
CMI: 
CMM_0818(tagD)
RMU: 
BCV: 
BFA: 
CFL: 
MPH: 
MLP_04890(tagD)
NCA: 
KFL: 
NML: 
SEN: 
BLO: 
OLS: 
LIL: 
LIC: 
LIC_11539(tagD)
LBJ: 
LBL: 
FSU: 
FNU: 
PGI: 
PG_2068(tagD)
FBA: 
AAE: 
aq_1368(tagD2)
TRQ: 
TME: 
MPZ: 
NMR: 
 » show all
Taxonomy
Reference
1  [PMID:13911452]
  Authors
SHAW DR.
  Title
Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol.
  Journal
Biochem. J. 82 (1962) 297-312.
Reference
2  [PMID:8393871]
  Authors
Park YS, Sweitzer TD, Dixon JE, Kent C
  Title
Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis.
  Journal
J. Biol. Chem. 268 (1993) 16648-54.
Reference
3  [PMID:11487587]
  Authors
Sanker S, Campbell HA, Kent C
  Title
Negative cooperativity of substrate binding but not enzyme activity in wild-type  and mutant forms of CTP:glycerol-3-phosphate cytidylyltransferase.
  Journal
J. Biol. Chem. 276 (2001) 37922-8.
Reference
4  [PMID:12637027]
  Authors
Badurina DS, Zolli-Juran M, Brown ED
  Title
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.
  Journal
Biochim. Biophys. Acta. 1646 (2003) 196-206.
Reference
5  [PMID:14506262]
  Authors
Pattridge KA, Weber CH, Friesen JA, Sanker S, Kent C, Ludwig ML
  Title
Glycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding  of CDP-glycerol and the role of lysine residues in catalysis.
  Journal
J. Biol. Chem. 278 (2003) 51863-71.
  Sequence
[bsu:BSU35740]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9027-11-6

DBGET integrated database retrieval system