KEGG   ENZYME: 2.7.7.46Help
Entry
EC 2.7.7.46                 Enzyme                                 

Name
gentamicin 2''-nucleotidyltransferase;
gentamicin 2''-adenylyltransferase;
aminoglycoside adenylyltransferase;
gentamycin 2''-nucleotidyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
NTP:gentamicin 2''-nucleotidyltransferase
Reaction(IUBMB)
nucleoside triphosphate + gentamicin = diphosphate + 2''-nucleotidylgentamicin [RN:R02432]
Reaction(KEGG)
Substrate
nucleoside triphosphate [CPD:C00201];
gentamicin [CPD:C00505]
Product
diphosphate [CPD:C00013];
2''-nucleotidylgentamicin [CPD:C03565]
Comment
ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin, tobramycin and sisomicin can also act as acceptors. The nucleotidyl residue is transferred to the 2-hydroxy of the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
History
EC 2.7.7.46 created 1976
Orthology
K17881  
aminoglycoside 2''-adenylyltransferase
Genes
ECLE: 
ECLN: 
ECLI: 
KPN: 
KPZ: 
KOK: 
KOC: 
KQU: 
CFD: 
KIN: 
PMP: 
Pmu_03410(aadB)
PPUH: 
ABY: 
ABAYE3622(aadB)
ABAL: 
 » show all
Taxonomy
Reference
1  [PMID:6281224]
  Authors
Angelatou F, Litsas SB, Kontomichalou P.
  Title
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa.
  Journal
J. Antibiot. (Tokyo). 35 (1982) 235-44.
Reference
2  [PMID:4946513]
  Authors
Naganawa H, Yagisawa M, Kondo S, Takeuchi T, Umezawa H.
  Title
The structure determination of an enzymatic inactivation product of 3',4'-dideoxykanamycin B.
  Journal
J. Antibiot. (Tokyo). 24 (1971) 913-4.
Reference
3  [PMID:4946512]
  Authors
Yagisawa M, Naganawa H, Kondo S, Hamada M, Takeuchi T.
  Title
Adenylyldideoxykanamycin B, a product of the inactivation of dideoxykanamycin B by Escherichia coli carrying R factor.
  Journal
J. Antibiot. (Tokyo). 24 (1971) 911-2.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-33-6

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