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Entry
EC 2.7.7.64                 Enzyme                                 

Name
UTP-monosaccharide-1-phosphate uridylyltransferase;
UDP-sugar pyrophosphorylase;
PsUSP
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Reaction(IUBMB)
UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide [RN:R08845]
Reaction(KEGG)
Substrate
UTP [CPD:C00075];
monosaccharide 1-phosphate [CPD:C00991]
Product
diphosphate [CPD:C00013];
UDP-monosaccharide [CPD:C05227]
Comment
Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].
History
EC 2.7.7.64 created 2006
Pathway
Pentose and glucuronate interconversions
Galactose metabolism
Ascorbate and aldarate metabolism
Amino sugar and nucleotide sugar metabolism
Metabolic pathways
Biosynthesis of antibiotics
Orthology
K12447  
UDP-sugar pyrophosphorylase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0214629.1(Lj0g3v0214629.1) Lj0g3v0214629.2(Lj0g3v0214629.2)
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
103485690(UGGPase)
RCU: 
JCU: 
POP: 
POPTR_0002s07790g(POPTRDRAFT_551400)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
4341967(OsJ_021664)
DOSA: 
Os06t0701200-01(Os06g0701200)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_10g028950(SORBIDRAFT_10g028950)
ZMA: 
100285949(TIDP2982) 100382378(GRMZM2G116586) 103625925(GRMZM2G396565)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OTA: 
BPG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
PCB: 
PBE: 
PVX: 
CPV: 
CHO: 
TGO: 
TET: 
PTM: 
SMIN: 
v1.2.004770.t1(symbB.v1.2.004770.t1) v1.2.011414.t1(symbB.v1.2.011414.t1)
PTI: 
TPS: 
AAF: 
PIF: 
PSOJ: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
CAA: 
 » show all
Taxonomy
Reference
1  [PMID:15326166]
  Authors
Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y.
  Title
UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.
  Journal
J. Biol. Chem. 279 (2004) 45728-36.
  Sequence
Reference
2  [PMID:4430676]
  Authors
Rudick VL, Weisman RA.
  Title
Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.
  Journal
J. Biol. Chem. 249 (1974) 7832-40.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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