| Entry |
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| Name |
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase;
D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase;
hldE (gene name);
rfaE (gene name)
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
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| Reaction(IUBMB) |
D-glycero-beta-D-manno-heptose 1-phosphate + ATP = ADP-D-glycero-beta-D-manno-heptose + diphosphate [RN: R05644]
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| Reaction(KEGG) |
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| Substrate |
D-glycero-beta-D-manno-heptose 1-phosphate [CPD: C07838];
ATP [CPD: C00002]
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| Product |
ADP-D-glycero-beta-D-manno-heptose [CPD: C06397];
diphosphate [CPD: C00013]
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| Comment |
The bifunctional protein hldE includes D-glycero-beta-D-manno-heptose-7-phosphate kinase and D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase activity (cf. EC 2.7.1.167). The enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core in Gram-negative bacteria.
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| Pathway |
| Lipopolysaccharide biosynthesis | | Metabolic pathways |
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| Orthology |
| D-beta-D-heptose 7-phosphate kinase / D-beta-D-heptose 1-phosphate adenosyltransferase |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | EBT: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YPB: | | YEN: | | YEP: | | YEY: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | PLU: | | PAY: | | BAK: | | BUH: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | CRO: | | SPE: | | SRR: | | SRS: | | SRA: | | SSZ: | | SMAF: | | SMW: | | PMR: | | EIC: | | ETR: | | ETD: | | ETC: | | BFL: | | BPN: | | BVA: | | BCHR: | | HDE: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | XNE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RIP: | | RAH: | | RAQ: | | RAA: | | PSI: | | MMK: | | ROR: | | SECT: | | SEHC: | | EBF: | | HIN: | | HIT: | | HIP: | | HIQ: | | HIF: | | HIL: | | HIU: | | HIE: | | HIZ: | | HDU: | | HAP: | | HPR: | | HSO: | | HSM: | | PMU: | | PMV: | | PUL: | | PMP: | | MSU: | | MHT: | | MHQ: | | MHX: | | APL: | | APJ: | | APA: | | ASU: | | ASI: | | AAP: | | AAT: | | AAO: | | AAN: | | GAN: | | BTO: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VVU: | | VVY: | | VVM: | | VPA: | | VPB: | | VHA: | | VSP: | | VEX: | | VEJ: | | VFU: | | VFI: | | VFM: | | VSA: | | PPR: | | VAN: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUU: | | PST: | | PSB: | | PSP: | | PFL: | | PFO: | | PFS: | | PFE: | | PFC: | | PPZ: | | PEN: | | PMY: | | PMK: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PBA: | | PFV: | | PDR: | | CJA: | | AVN: | | AVL: | | AVD: | | SON: | | SDN: | | SFR: | | SAZ: | | SBL: | | SBM: | | SBN: | | SBP: | | SBT: | | SBS: | | SBB: | | SLO: | | SPC: | | SHP: | | SSE: | | SPL: | | SHE: | | SHM: | | SHN: | | SHW: | | SHL: | | SWD: | | SWP: | | SVO: | | PHA: | | PSM: | | MAQ: | | AMC: | | ALT: | | GNI: | | PIN: | | PSY: | | FBL: | | CBU: | | CBS: | | CBD: | | CBG: | | CBC: | | MCA: | | MMT: | | TCX: | | TCY: | | MEJ: | | MEC: | | CYQ: | | NOC: | | NHL: | | NWA: | | ALV: | | TVI: | | TMB: | | AEH: | | HHA: | | TKM: | | TNI: | | HCH: | | CSA: | | HEL: | | ABO: | | ADI: | | KKO: | | MMW: | | MME: | | MPC: | | TOL: | | AHA: | | ASA: | | AVR: | | TAU: | | OCE: | | DNO: | | SAGA: | | BCT: | | BXE: | | BPY: | | NMU: | | AZO: | | AZA: | | MFA: | | MMB: | | MEH: | | MEI: | | MEP: | | HPY: | | HEO: | | HPJ: | | HPA: | | HPS: | | HHP: | | HHQ: | | HHR: | | HPG: | | HPP: | | HPB: | | HPL: | | HPC: | | HCA: | | HPM: | | HPE: | | HPO: | | HPI: | | HPQ: | | HPW: | | HPU: | | HEF: | | HPF: | | HEQ: | | HEX: | | HPT: | | HPZ: | | HPV: | | HPX: | | HEN: | | HPH: | | HEG: | | HPN: | | HEP: | | HEU: | | HES: | | HCN: | | HPD: | | HEY: | | HER: | | HEI: | | HPYA: | | HPYK: | | HPYO: | | HPYL: | | HHE: | | HAC: | | HMS: | | HFE: | | HBI: | | HCE: | | HCM: | | HCP: | | HCB: | | WSU: | | TDN: | | SUA: | | SKU: | | SULR: | | CJE: | | CJB: | | CJJ: | | CJU: | | CJN: | | CJI: | | CJM: | | CJS: | | CJP: | | CJR: | | CJD: | | CFF: | | CCV: | | CCO: | | CLA: | | ABU: | | ABT: | | ANT: | | SDL: | | SBA: | | NSA: | | NIS: | | NAM: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | PCA: | | PPD: | | DDS: | | DAK: | | DSF: | | DAL: | | DAT: | | DTO: | | DAO: | | DTI: | | DBR: | | MLO: | | MCI: | | MOP: | | MAM: | | PLA: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | AOL: | | XAU: | | AZC: | | BID: | | MSL: | | CCR: | | CCS: | | CAK: | | CSE: | | PZU: | | BSB: | | HNE: | | GOX: | | GOH: | | GBE: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | RRU: | | RRF: | | RCE: | | RPM: | | MAG: | | AZL: | | ALI: | | ABS: | | TMO: | | APB: | | MAI: | | MAN: | | APC: | | MGM: | | DIN: | | TMR: | | VPR: | | SSG: | | SRI: | | MED: | | AFN: | | AIN: | | MTS: | | PCU: | | PUV: | | WCH: | | SNG: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | NKO: | | PSN: | | SHG: | | AMU: | | GAU: | | PLM: | | PBS: | | IPA: | | SACI: | | PHM: | | TAI: | | ACO: | | TLI: | | AMO: | | GLP: | | CTHE: | | STI: | | LFC: | | LFI: | | DAP: | | TID: | | TTR: | |
» show all
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| Reference |
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| Authors |
Valvano MA, Marolda CL, Bittner M, Glaskin-Clay M, Simon TL, Klena JD |
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| Title |
The rfaE gene from Escherichia coli encodes a bifunctional protein involved in biosynthesis of the lipopolysaccharide core precursor ADP-L-glycero-D-manno-heptose. |
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| Journal |
J. Bacteriol. 182 (2000) 488-97. |
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| Reference |
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| Authors |
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P |
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| Title |
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli. |
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| Journal |
J. Bacteriol. 184 (2002) 363-9. |
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| Reference |
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| Authors |
Valvano MA, Messner P, Kosma P |
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| Title |
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides. |
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| Journal |
Microbiology. 148 (2002) 1979-89. |
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| Reference |
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| Authors |
Wang L, Huang H, Nguyen HH, Allen KN, Mariano PS, Dunaway-Mariano D |
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| Title |
Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB). |
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| Journal |
Biochemistry. 49 (2010) 1072-81. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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