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Entry
EC 2.7.7.71                 Enzyme                                 

Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]
Reaction(KEGG)
Substrate
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]
Product
GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
History
EC 2.7.7.71 created 2010
Pathway
Lipopolysaccharide biosynthesis
Orthology
K15669  
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Genes
YPB: 
YPQ: 
PLU: 
plu4824(wblY)
PPB: 
SBB: 
AMAG: 
TVI: 
HCH: 
TOL: 
TOR: 
REU: 
BMA: 
BMA2294(hddC)
BMV: 
BML: 
BMN: 
BMAL: 
BPS: 
BPSL2794(wcbM)
BPM: 
BPL: 
BPD: 
BPR: 
BPSE: 
BPSM: 
BPSU: 
BPSD: 
BPZ: 
BPQ: 
BPK: 
BPSH: 
BTD: 
BUT: 
NET: 
MEH: 
CJE: 
Cj1423c(hddC)
CJB: 
CJJ: 
CJN: 
CJS: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJR: 
CJD: 
CJZ: 
CJX: 
CCF: 
ANT: 
GLO: 
DMA: 
DTI: 
HMR: 
CSE: 
CAC: 
CAE: 
CAY: 
CSH: 
CSO: 
DEC: 
BPRM: 
EYY: 
SNG: 
TLI: 
AMO: 
SYZ: 
SYY: 
SYNGTS_2223(slr0007)
SYT: 
SYNGTI_2222(slr0007)
SYS: 
SYNPCCN_2221(slr0007)
SYQ: 
SYNPCCP_2221(slr0007)
SYJ: 
MAR: 
CAN: 
PMH: 
BTH: 
BFG: 
CPI: 
NKO: 
PAA: 
NDE: 
LFI: 
TCM: 
 » show all
Taxonomy
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J. Biol. Chem. 276 (2001) 20935-44.
  Sequence
[up:Q9AGY6]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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