KEGG   ENZYME: 2.7.7.74Help
Entry
EC 2.7.7.74                 Enzyme                                 

Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
Inositol phosphate metabolism
Orthology
K07281  
1L-myo-inositol 1-phosphate cytidylyltransferase
Genes
MTHD: 
ENM: 
NAR: 
STAX: 
GBE: 
GDI: 
GDI0629(hasC)
GDJ: 
TMR: 
TPZ: 
RXY: 
TTR: 
RMR: 
RMG: 
AAE: 
aq_1367(spsI)
PMX: 
TTK: 
TID: 
MIF: 
MIG: 
AFU: 
AFG: 
APO: 
AVE: 
AST: 
FPL: 
GAC: 
GAH: 
PHO: 
PH1219(PH1219)
PAB: 
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
PYC: 
TKO: 
TON: 
TGA: 
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
TEU: 
TCH: 
PPAC: 
APE: 
ACJ: 
IAG: 
HBU: 
PFM: 
PDL: 
TPE: 
THB: 
KCR: 
BARC: 
LOKI: 
 » show all
Taxonomy
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J. Bacteriol. 189 (2007) 5405-12.
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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