KEGG   ENZYME: 2.7.7.78Help
Entry
EC 2.7.7.78                 Enzyme                                 

Name
GDP-D-glucose phosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
GDP:alpha-D-glucose 1-phosphate guanylyltransferase
Reaction(IUBMB)
GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP [RN:R09752]
Reaction(KEGG)
Substrate
GDP-alpha-D-glucose [CPD:C00394];
phosphate [CPD:C00009]
Product
alpha-D-glucose 1-phosphate [CPD:C00103];
GDP [CPD:C00035]
Comment
The enzyme may be involved in prevention of misincorporation of glucose in place of mannose residues into glycoconjugates i.e. to remove accidentally produced GDP-alpha-D-glucose. Activities with GDP-L-galactose, GDP-D-mannose and UDP-D-glucose are all less than 3% that with GDP-D-glucose.
History
EC 2.7.7.78 created 2011
Orthology
K15630  
GDP-D-glucose phosphorylase
Genes
HSA: 
390637(GDPGP1)
PTR: 
745569(GDPGP1)
PPS: 
100982804(GDPGP1)
GGO: 
101152503(GDPGP1)
PON: 
100444173(GDPGP1)
NLE: 
100594834(GDPGP1)
MCC: 
701954(GDPGP1)
MCF: 
102121174(GDPGP1)
CJC: 
100392315(GDPGP1)
MMU: 
269952(Gdpgp1)
RNO: 
308763(Gdpgp1)
CGE: 
100772319(Gdpgp1)
TUP: 
102501837(GDPGP1)
CFA: 
479045(GDPGP1)
AML: 
UMR: 
103660194(GDPGP1)
FCA: 
101082062(GDPGP1)
PTG: 
102960896(GDPGP1)
BTA: 
522909(GDPGP1)
BOM: 
102288281(GDPGP1)
PHD: 
102334089(GDPGP1)
CHX: 
102169222(GDPGP1)
OAS: 
101105361(GDPGP1)
SSC: 
CFR: 
102510192(GDPGP1)
BACU: 
102999980(GDPGP1)
LVE: 
103071553(GDPGP1)
ECB: 
100069039(GDPGP1)
MYB: 
102240979(GDPGP1)
MYD: 
102759603(GDPGP1)
PALE: 
102885796(GDPGP1)
MDO: 
100015004(GDPGP1)
SHR: 
100923815(GDPGP1)
OAA: 
100081924(GDPGP1)
GGA: 
PHI: 
102109647(GDPGP1)
ASN: 
102383638(GDPGP1)
AMJ: 
102563294(GDPGP1)
PSS: 
CMY: 
102940662(GDPGP1)
PBI: 
103057762(GDPGP1)
XLA: 
100126619(gdpgp1)
XTR: 
779852(gdpgp1)
DRE: 
560896(gdpgp1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348470(GDPGP1)
CMK: 
103188517(gdpgp1)
BFO: 
CIN: 
SPU: 
DSI: 
NVI: 
BMOR: 
API: 
ISC: 
CEL: 
CBR: 
BMY: 
HRO: 
LGI: 
NVE: 
HMG: 
TAD: 
 » show all
Taxonomy
Reference
1  [PMID:21507950]
  Authors
Adler LN, Gomez TA, Clarke SG, Linster CL
  Title
A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.
  Journal
J. Biol. Chem. 286 (2011) 21511-23.
  Sequence
[cel:CELE_C10F3.4] [hsa:390637] [mmu:269952]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system