KEGG   ENZYME: 2.7.7.82Help
Entry
EC 2.7.7.82                 Enzyme                                 

Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]
Reaction(KEGG)
Substrate
CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]
Product
CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K18431  
CMP-N,N'-diacetyllegionaminic acid synthase
Genes
LPN: 
lpg0751(neuA)
LPH: 
LPV_0877(neuA)
LPO: 
LPO_0832(neuA)
LPU: 
LPM: 
LP6_0731(neuA)
LPF: 
lpl0788(neuA)
LPP: 
lpp0817(neuA)
LPC: 
LPC_2541(neuA)
LPA: 
lpa_01159(neuA)
LPE: 
FPH: 
FPI: 
FPX: 
HCP: 
HCB: 
SULR: 
CJE: 
Cj1331(ptmB)
CJB: 
CJI: 
CJSA_1267(ptmB)
CJS: 
CJP: 
CJEJ: 
CJEU: 
CJEN: 
CJEI: 
CJER: 
CJY: 
QZ67_01467(legF_2)
CJQ: 
UC78_1274(legF_2)
CJL: 
CJW: 
CJR: 
CJE1520(ptmB)
CJD: 
CJZ: 
CJX: 
CCO: 
CLA: 
Cla_1229(ptmB)
CCOL: 
CCC: 
CCQ: 
CCF: 
CCY: 
CCOI: 
CCOF: 
VC76_06680(legF_2)
CIS: 
CINS_1190(legF)
CVO: 
CVOL_1210(legF)
CSM: 
CSF: 
ABT: 
ARC: 
PPY: 
PTA: 
EFC: 
EFAU: 
EFU: 
CNO: 
CBL: 
CBB: 
CBN: 
CKL: 
CKL_2466(neuA)
CKR: 
CCB: 
CTH: 
CTX: 
CCL: 
BPB: 
bpr_I0432(neuA1)
CLE: 
CST: 
DDL: 
DOR: 
AWO: 
TIT: 
TXY: 
TSH: 
HPK: 
SCD: 
LIL: 
LA_1605(neuA)
LIE: 
LIF_A1292(neuA)
LIC: 
LIC_12177(neuA)
 » show all
Taxonomy
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry. 47 (2008) 3272-82.
  Sequence
[lpn:lpg0751]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology. 19 (2009) 715-25.
  Sequence
[cje:Cj1331]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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