KEGG   ENZYME: 2.7.7.94Help
Entry
EC 2.7.7.94                 Enzyme                                 

Name
4-hydroxyphenylalkanoate adenylyltransferase;
fadD29 (gene name);
4-hydroxyphenylalkanoate adenylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:4-hydroxyphenylalkanoate adenylyltransferase
Reaction(IUBMB)
(1) ATP + 17-(4-hydroxyphenyl)heptadecanoate = diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl adenylate [RN:R11537];
(2) ATP + 19-(4-hydroxyphenyl)nonadecanoate = diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl adenylate [RN:R11538]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
17-(4-hydroxyphenyl)heptadecanoate [CPD:C21446];
19-(4-hydroxyphenyl)nonadecanoate [CPD:C21448]
Product
diphosphate [CPD:C00013];
17-(4-hydroxyphenyl)heptadecanoyl adenylate [CPD:C21445];
19-(4-hydroxyphenyl)nonadecanoyl adenylate [CPD:C21447]
Comment
The mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to the phenolphthiocerol/phthiocerol polyketide synthase.
History
EC 2.7.7.94 created 2016
Orthology
K21059  
4-hydroxyphenylalkanoate adenylyltransferase
Genes
MTU: 
Rv2950c(fadD29)
MTV: 
MTC: 
MRA: 
MRA_2977(fadD29)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTE: 
MTUR: 
CFBS_3109(fadD29)
MTL: 
MTO: 
MTCTRI2_3008(fadD29)
MTD: 
UDA_2950c(fadD29)
MTN: 
ERDMAN_3232(fadD29)
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
HKBT1_3096(fadD29)
MTUU: 
HKBT2_3101(fadD29)
MTQ: 
HKBS1_3103(fadD29)
MBO: 
Mb2974c(fadD29)
MBB: 
BCG_2971c(fadD29)
MBT: 
JTY_2966(fadD29)
MBM: 
BCGMEX_2966c(fadD29)
MBK: 
MBX: 
MBZ: 
MAF: 
MAF_29550(fadD29)
MCE: 
MCAN_29701(fadD29)
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
ML0132(fadD29)
MLB: 
MLBr00132(fadD29)
MUL: 
MUL_2002(fadD29)
MMI: 
MMAR_1759(fadD29)
MMAE: 
MLI: 
MULP_01914(fadD29)
MKN: 
MKS: 
MKI: 
MHAD: 
 » show all
Taxonomy
Reference
1  [PMID:20553505]
  Authors
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
  Title
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
  Journal
FEBS. J. 277 (2010) 2715-25.
  Sequence
[mtu:Rv2950c]
Reference
2  [PMID:25561717]
  Authors
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
  Title
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
  Journal
J. Bacteriol. 197 (2015) 1040-50.
  Sequence
[mmi:MMAR_1759]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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