KEGG   ENZYME: 2.7.7.96Help
Entry
EC 2.7.7.96                 Enzyme                                 

Name
ADP-D-ribose pyrophosphorylase;
NUDIX5;
NUDT5 (gene name);
diphosphate---ADP-D-ribose adenylyltransferase;
diphosphate adenylyltransferase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:D-ribose 5-phosphate adenylyltransferase
Reaction(IUBMB)
ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose [RN:R11553]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
D-ribose 5-phosphate [CPD:C00117]
Product
diphosphate [CPD:C00013];
ADP-D-ribose [CPD:C00301]
Comment
The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC 3.6.1.13, ADP-ribose diphosphatase. cf. EC 2.7.7.35, ADP ribose phosphorylase.
History
EC 2.7.7.96 created 2016
Orthology
K13987  ADP-sugar pyrophosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase
Genes
HSA: 11164(NUDT5)
PTR: 450306(NUDT5)
PPS: 100977876(NUDT5)
GGO: 101148720(NUDT5)
PON: 100172071(NUDT5)
NLE: 100600434(NUDT5)
MCC: 694368(NUDT5)
MCF: 102118162(NUDT5)
CSAB: 103237893(NUDT5)
RRO: 104664884(NUDT5)
RBB: 108538530(NUDT5)
CJC: 100414997(NUDT5)
SBQ: 101035792(NUDT5)
MMU: 53893(Nudt5)
RNO: 361274(Nudt5)
CGE: 100772118(Nudt5)
NGI: 103738702(Nudt5) 108491232
HGL: 101722031(Nudt5)
CCAN: 109682446(Nudt5)
OCU: 100341885(NUDT5)
TUP: 102481118(NUDT5)
CFA: 478006(NUDT5)
AML: 100482621(NUDT5)
UMR: 103676270(NUDT5)
ORO: 101364423(NUDT5)
FCA: 101084635(NUDT5)
PTG: 102950979(NUDT5)
AJU: 106971034(NUDT5)
BTA: 614149(NUDT5)
BOM: 102283030(NUDT5)
BIU: 109567873(NUDT5)
PHD: 102331579(NUDT5)
CHX: 102174220(NUDT5)
OAS: 101117779(NUDT5)
SSC: 100511529(NUDT5)
CFR: 102506081(NUDT5)
CDK: 105100309(NUDT5)
BACU: 103014516(NUDT5)
LVE: 103088541(NUDT5)
OOR: 101271940(NUDT5)
ECB: 100056812(NUDT5)
EPZ: 103563355(NUDT5)
EAI: 106826880 106836935(NUDT5)
MYB: 102243782(NUDT5)
MYD: 102755333(NUDT5)
HAI: 109390483(NUDT5)
RSS: 109433767(NUDT5)
PALE: 102895562(NUDT5)
LAV: 100677273(NUDT5)
TMU: 101350654
MDO: 100013664(NUDT5)
SHR: 100926504(NUDT5)
OAA: 100084986(NUDT5)
GGA: 426368(NUDT5)
MGP: 100538350(NUDT5)
CJO: 107317497(NUDT5)
APLA: 101792445(NUDT5)
ACYG: 106046205(NUDT5)
TGU: 100227819(NUDT5)
GFR: 102042579(NUDT5)
FAB: 101811306(NUDT5)
PHI: 102100920(NUDT5)
PMAJ: 107204378(NUDT5)
CCW: 104694502(NUDT5)
FPG: 101911346(NUDT5)
FCH: 102058952(NUDT5)
CLV: 102084865(NUDT5)
EGZ: 104135774(NUDT5)
AAM: 106485418(NUDT5)
ASN: 102373059(NUDT5)
AMJ: 102562108(NUDT5)
PSS: 102460805(NUDT5)
CMY: 102941929(NUDT5)
CPIC: 101938331(NUDT5)
ACS: 100567214(nudt5)
PVT: 110081210(NUDT5)
PBI: 103064447(NUDT5)
GJA: 107111067(NUDT5)
XLA: 108713048(nudt5.S) 432263(nudt5.L)
XTR: 549367(nudt5)
NPR: 108784813(NUDT5)
DRE: 415176(nudt5)
SGH: 107580386 107584018(nudt5)
CCAR: 109054944 109066493(nudt5)
IPU: 100528701(nudt5)
AMEX: 103033374(nudt5)
LCO: 104930602(nudt5)
NCC: 104955336(nudt5)
MZE: 101470680(nudt5)
OLA: 101161229(nudt5)
XMA: 102224507(nudt5)
PRET: 103459674(nudt5)
NFU: 107382591(nudt5)
CSEM: 103383109(nudt5)
LCF: 108874307(nudt5) 108891412
HCQ: 109528866(nudt5)
BPEC: 110161767(nudt5)
SASA: 100196024(nudt5) 106609278(NUDT5)
ELS: 105028521(nudt5)
SFM: 108931529(nudt5)
LCM: 102359306(NUDT5)
CMK: 103187912(nudt5)
SPU: 580253
APLC: 110987738
SKO: 100371378
ZNE: 110831927
FCD: 110850781
TUT: 107360643
CRG: 105336592
MYI: 110448861
OBI: 106881854
LAK: 106166567
 » show all
Taxonomy
Reference
1  [PMID:27257257]
  Authors
Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M
  Title
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
  Journal
Science. 352 (2016) 1221-5.
  Sequence
[hsa:11164]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.96
IUBMB Enzyme Nomenclature: 2.7.7.96
ExPASy - ENZYME nomenclature database: 2.7.7.96
BRENDA, the Enzyme Database: 2.7.7.96

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