KEGG   ENZYME: 2.7.7.97Help
Entry
EC 2.7.7.97                 Enzyme                                 

Name
3-hydroxy-4-methylanthranilate adenylyltransferase;
acmA (gene name);
sibE (gene name);
actinomycin synthase I;
4-MHA-activating enzyme;
ACMS I;
actinomycin synthetase I;
4-MHA pentapeptide lactone synthase AcmA
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:3-hydroxy-4-methylanthranilate adenylyltransferase
Reaction(IUBMB)
ATP + 3-hydroxy-4-methylanthranilate = diphosphate + 3-hydroxy-4-methylanthranilyl-adenylate [RN:R11554]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
3-hydroxy-4-methylanthranilate [CPD:C03986]
Product
diphosphate [CPD:C00013];
3-hydroxy-4-methylanthranilyl-adenylate
Comment
The enzyme, characterized from the bacteria Streptomyces anulatus and Streptosporangium sibiricum, activates 3-hydroxy-4-methylanthranilate, a precursor of actinomycin antibiotics and the antitumor antibiotic sibiromycin, to an adenylate form, so it can be loaded onto a dedicated aryl-carrier protein.
History
EC 2.7.7.97 created 2016
Orthology
K21284  
3-hydroxy-4-methylanthranilate adenylyltransferase
Genes
NBR: 
SCB: 
SBH: 
SRC: 
SLD: 
KSK: 
RTX: 
RTC: 
KFL: 
SESP: 
KAL: 
KPHY: 
AHM: 
ACTI: 
ACAD: 
ALL: 
STP: 
SAQ: 
MAU: 
MIL: 
ACTN: 
CAI: 
 » show all
Taxonomy
Reference
1  [PMID:10212227]
  Authors
Pfennig F, Schauwecker F, Keller U
  Title
Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces.
  Journal
J. Biol. Chem. 274 (1999) 12508-16.
  Sequence
Reference
2  [PMID:21612226]
  Authors
Giessen TW, Kraas FI, Marahiel MA
  Title
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.
  Journal
Biochemistry. 50 (2011) 5680-92.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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