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Entry
EC 2.7.7.98                 Enzyme                                 

Name
4-hydroxybenzoate adenylyltransferase;
fadD22 (gene name);
4-hydroxybenzoate adenylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:4-hydroxybenzoate adenylyltransferase
Reaction(IUBMB)
ATP + 4-hydroxybenzoate = diphosphate + 4-hydroxybenzoyl adenylate [RN:R11608]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156]
Product
diphosphate [CPD:C00013];
4-hydroxybenzoyl adenylate [CPD:C21497]
Comment
This mycobacterial enzyme participates in the biosynthesis of phenolphthiocerols. Following the substrate's activation by adenylation, it is transferred to an acyl-carrier protein domain within the enzyme, from which it is transferred to EC 2.3.1.261, 4-hydroxyphenylalkanoate synthase.
History
EC 2.7.7.98 created 2017
Orthology
K12424  
4-hydroxybenzoate adenylyltransferase
Genes
MTU: 
Rv2948c(fadD22)
MTV: 
MTC: 
MRA: 
MRA_2975(fadD22)
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
CFBS_3107(fadD22)
MTL: 
MTO: 
MTCTRI2_3006(fadD22)
MTD: 
UDA_2948c(fadD22)
MTN: 
ERDMAN_3231(fadD22)
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MTUT: 
HKBT1_3094(fadD22)
MTUU: 
HKBT2_3099(fadD22)
MTQ: 
HKBS1_3101(fadD22)
MBO: 
Mb2972c(fadD22)
MBB: 
BCG_2969c(fadD22)
MBT: 
JTY_2964(fadD22)
MBM: 
BCGMEX_2964c(fadD22)
MBK: 
MBX: 
MBZ: 
MAF: 
MAF_29530(fadD22)
MCE: 
MCAN_29681(fadD22)
MCQ: 
MCV: 
MCX: 
MCZ: 
MMIC: 
MLE: 
ML0134(fadD22)
MLB: 
MLBr00134(fadD22)
MUL: 
MUL_2004(fadD22)
MMI: 
MMAR_1761(fadD22)
MMAE: 
MLI: 
MULP_01916(fadD22)
MKN: 
MKS: 
MKI: 
MHAD: 
SCT: 
SCY: 
SBH: 
SRC: 
SXI: 
STRM: 
STSI: 
SESP: 
KPHY: 
 » show all
Taxonomy
Reference
1  [PMID:20553505]
  Authors
Simeone R, Leger M, Constant P, Malaga W, Marrakchi H, Daffe M, Guilhot C, Chalut C
  Title
Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis.
  Journal
FEBS. J. 277 (2010) 2715-25.
  Sequence
[mtu:Rv2948c]
Reference
2  [PMID:25561717]
  Authors
Vergnolle O, Chavadi SS, Edupuganti UR, Mohandas P, Chan C, Zeng J, Kopylov M, Angelo NG, Warren JD, Soll CE, Quadri LE
  Title
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
  Journal
J. Bacteriol. 197 (2015) 1040-50.
  Sequence
[mmi:MMAR_1761]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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